Sumbu Z L, Thonart P, Bechet J
Appl Environ Microbiol. 1983 Jan;45(1):110-5. doi: 10.1128/aem.45.1.110-115.1983.
The action of patulin on Saccharomyces cerevisiae was studied. At weak doses, the drug inhibited growth, but inhibition was transient. After 10 min, syntheses of rRNA, tRNA, and probably mRNA were blocked; this was shown by radioactive precursor incorporation assays and gel electrophoresis of RNAs. After recovery of growth, patulin disappeared from the medium. It seemed that this degradation resulted from the activity of an inducible enzymatic system. Induced cells resisted very high patulin concentrations.
研究了展青霉素对酿酒酵母的作用。在低剂量时，该药物抑制生长，但抑制是短暂的。10分钟后，rRNA、tRNA以及可能的mRNA的合成被阻断；这通过放射性前体掺入试验和RNA的凝胶电泳得以证明。生长恢复后，展青霉素从培养基中消失。似乎这种降解是由一种可诱导的酶系统的活性导致的。诱导的细胞能抵抗非常高浓度的展青霉素。
