酿酒酵母中一条新染色体的证据。
Evidence for a new chromosome in Saccharomyces cerevisiae.
作者信息
Wickner R B, Boutelet F, Hilger F
出版信息
Mol Cell Biol. 1983 Mar;3(3):415-20. doi: 10.1128/mcb.3.3.415-420.1983.
Abstract
The current yeast map has 16 chromosomes, each originally defined by a centromere-linked gene unlinked to previously defined centromere markers. We examined four genes, cly2, KRB1, AMY2, and tsm0115, each centromere linked, but previously thought to be not on chromosomes I to XVI. We found that AMY2 is linked to cly2, and both are on chromosome II. tsm0115 is on the left arm of chromosome XVI. We confirm the earlier evidence that KRB1 is not on chromosomes I through XVI. This gene thus defines a new chromosome XVII. We also report meiotic linkage of met4 and pet8 (on chromosome XIV), confirming the connection between the petx-kex2 fragment of XIV and the centromere of XIV.
摘要
当前的酵母图谱有16条染色体，每条染色体最初由一个与着丝粒相连的基因定义，该基因与先前定义的着丝粒标记不连锁。我们研究了四个基因，cly2、KRB1、AMY2和tsm0115，每个基因都与着丝粒相连，但先前认为不在I至XVI号染色体上。我们发现AMY2与cly2连锁，且二者都在II号染色体上。tsm0115在XVI号染色体的左臂上。我们证实了先前的证据，即KRB1不在I至XVI号染色体上。因此，该基因定义了一条新的XVII号染色体。我们还报告了met4和pet8（在XIV号染色体上）的减数分裂连锁，证实了XIV号染色体的petx-kex2片段与XIV号染色体着丝粒之间的联系。
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