Schiffman P L, Trontell M C, Mazar M F, Edelman N H
Chest. 1983 Dec;84(6):695-8. doi: 10.1378/chest.84.6.695.
Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (delta V1/delta PCO2) and response to an inspiratory flow resistive load (change in delta P100/delta PCO2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in delta V1/delta PCO2 from 2.51 +/- .36 to 2.09 +/- .34 L/min/mm Hg (p less than 0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency.
由于已知睡眠会降低通气驱动，且睡眠剥夺是通气衰竭的常见伴随情况，我们对13名健康志愿者在正常睡眠一晚后以及睡眠剥夺24小时后对二氧化碳的通气反应（ΔV1/ΔPCO2）和对吸气流量阻力负荷的反应（负荷时ΔP100/ΔPCO2的变化）进行了测试。睡眠剥夺与ΔV1/ΔPCO2从2.51±0.36显著降至2.09±0.34L/min/mm Hg相关（p<0.02）。然而，在睡眠剥夺期间负荷补偿得以保留。由于许多急性病患者存在睡眠剥夺，通气驱动的相关降低可能在进行性呼吸功能不全中起作用。
