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Simple and rapid high-pressure liquid chromatographic simultaneous determination of aspirin, salicylic acid, and salicyluric acid in plasma.

作者信息

Peng G W, Gadalla M A, Smith V, Peng A, Chiou W L

出版信息

J Pharm Sci. 1978 May;67(5):710-2. doi: 10.1002/jps.2600670540.

DOI:10.1002/jps.2600670540
PMID:641818
Abstract

A rapid and sensitive high-pressure liquid chromatographic assay was developed for aspirin, salicylic acid, and salicyluric acid in plasma. The procedure involves the solvent extraction of these compounds from plasma and separation using a reversed-phase column eluted by acidified aqueous acetonitrile. Small quantitites of aspirin can be assayed directly in the presence of a large quantity of salicylic acid. The assay is also free from blank interference.

摘要

相似文献

1
Simple and rapid high-pressure liquid chromatographic simultaneous determination of aspirin, salicylic acid, and salicyluric acid in plasma.
J Pharm Sci. 1978 May;67(5):710-2. doi: 10.1002/jps.2600670540.
2
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Ther Drug Monit. 1987 Jun;9(2):243-7. doi: 10.1097/00007691-198706000-00020.

引用本文的文献

1
Monitoring plasma concentrations of salicylate.监测水杨酸盐的血浆浓度。
Clin Pharmacokinet. 1980 Sep-Oct;5(5):424-40. doi: 10.2165/00003088-198005050-00002.
2
High-pressure liquid chromatographic determination of acetylsalicylic acid, salicylic acid, diflunisal, indomethacin, indoprofen and indobufen.
Eur J Clin Pharmacol. 1981;20(5):375-8. doi: 10.1007/BF00615408.
3
The influence of maternal protein deficiency on the placental transfer of salicylate in rats.母体蛋白质缺乏对大鼠水杨酸盐胎盘转运的影响。
Br J Pharmacol. 1983 Jan;78(1):233-8. doi: 10.1111/j.1476-5381.1983.tb09384.x.
4
Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats.年龄、性别、妊娠及蛋白质-热量营养不良对大鼠水杨酸盐药代动力学的影响。
Br J Pharmacol. 1984 May;82(1):241-8. doi: 10.1111/j.1476-5381.1984.tb16464.x.
5
Influence of intravenous acetylsalicylic acid and sodium salicylate on human renal function and lithium clearance.静脉注射乙酰水杨酸和水杨酸钠对人体肾功能及锂清除率的影响。
Eur J Clin Pharmacol. 1985;29(4):435-41. doi: 10.1007/BF00613458.
6
Clinical pharmacokinetics of the salicylates.水杨酸盐类的临床药代动力学
Clin Pharmacokinet. 1985 Mar-Apr;10(2):164-77. doi: 10.2165/00003088-198510020-00004.
7
Modification of transplacental distribution of salicylate in rats by acidosis and alkalosis.酸中毒和碱中毒对大鼠水杨酸盐经胎盘转运分布的影响。
Br J Pharmacol. 1988 Apr;93(4):978-84. doi: 10.1111/j.1476-5381.1988.tb11488.x.