粪肠球菌中诱导质粒转移的细菌性信息素cAD1的分离与结构
Isolation and structure of the bacterial sex pheromone, cAD1, that induces plasmid transfer in Streptococcus faecalis.
作者信息
Mori M, Sakagami Y, Narita M, Isogai A, Fujino M, Kitada C, Craig R A, Clewell D B, Suzuki A
出版信息
FEBS Lett. 1984 Dec 3;178(1):97-100. doi: 10.1016/0014-5793(84)81248-x.
The Streptococcus faecalis sex pheromone cAD1, which is involved in the conjugative transfer of the hemolysin plasmid pAD1, has been isolated and its structure determined. Its Mr is 818 and its amino acid sequence is H-Leu-Phe-Ser-Leu-Val-Leu-Ala-Gly-OH. A replicate of the pheromone synthesized by the liquid-phase method showed the same biological activity and chromatographic behavior as the isolated cAD1. Pheromone activity was detectable at a concentration of approximately 5 X 10(-11) M.
粪肠球菌性信息素cAD1参与溶血素质粒pAD1的接合转移，现已分离出来并确定了其结构。其相对分子质量为818，氨基酸序列为H-亮氨酸-苯丙氨酸-丝氨酸-亮氨酸-缬氨酸-亮氨酸-丙氨酸-甘氨酸-OH。通过液相法合成的信息素复制品显示出与分离出的cAD1相同的生物活性和色谱行为。在浓度约为5×10⁻¹¹ M时可检测到信息素活性。
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