兔对携带宋内志贺氏菌质粒的伤寒沙门氏菌菌株的肠道免疫球蛋白A反应。
Intestinal immunoglobulin A responses in rabbits to a Salmonella typhi strain harboring a Shigella sonnei plasmid.
作者信息
Keren D F, Collins H H, Baron L S, Kopecko D J, Formal S B
出版信息
Infect Immun. 1982 Jul;37(1):387-9. doi: 10.1128/iai.37.1.387-389.1982.
Abstract
Salmonella typhi 5076-IC, which contains a plasmid that encodes the form I antigen of Shigella sonnei and which expresses S. typhi 9 and 12 and S. sonnei form I antigens, was used to immunize rabbits via chronically isolated ileal loops. Intestinal immunoglobulin A activity was detected against S. typhi, S. sonnei form I, and S. typhi strain 5076-IC. Thus S. typhi 5076-IC can effectively elicit mucosal immunoglobulin A to both S. typhi and S. sonnei.
摘要
伤寒沙门氏菌5076 - IC含有一个编码宋内志贺氏菌I型抗原的质粒，并表达伤寒沙门氏菌9型和12型抗原以及宋内志贺氏菌I型抗原，通过长期分离的回肠袢用于免疫兔子。检测到针对伤寒沙门氏菌、宋内志贺氏菌I型和伤寒沙门氏菌菌株5076 - IC的肠道免疫球蛋白A活性。因此，伤寒沙门氏菌5076 - IC可以有效地引发针对伤寒沙门氏菌和宋内志贺氏菌的粘膜免疫球蛋白A。
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