Wynder E L, Hill P, Laakso K, Littner R, Kettunen K
Cancer. 1981 Mar 15;47(6):1444-50. doi: 10.1002/1097-0142(19810315)47:6<1444::aid-cncr2820470634>3.0.co;2-a.
Breast fluid was collected from 244 nonlactating Finnish women with no known breast disease and analyzed with respect to various epidemiologic and hormonal parameters commonly associated with breast cancer risk. The data obtained permit characterization of women with breast secretory ability and provide fundamental information on the hormone composition of breast fluid in a nondiseased population. No association was found between any epidemiologic variables (e.g., age, marital status, the number of pregnancies, the age of first pregnancy) and the ability to secrete a measurable amount of breast fluid. In addition, there appeared to be no correlation between prolactin and estrogen levels in serum and those in breast fluid within individual subjects. However, the median breast fluid prolactin level was approximately two-fold greater and the median breast fluid estrogen level was about six-fold greater than the corresponding serum values. It appears that breast ductal epithelial cells can actively transport both steroid and polypeptide hormones across a concentration barrier. Further metabolic epidemiologic investigations of hormones and potential carcinogens in the breast fluid from populations with high and low risks for breast cancer are suggested.
从244名无已知乳腺疾病的非哺乳期芬兰女性中收集了乳腺液，并针对通常与乳腺癌风险相关的各种流行病学和激素参数进行了分析。所获得的数据有助于对具有乳腺分泌能力的女性进行特征描述，并提供关于无疾病人群乳腺液激素组成的基础信息。未发现任何流行病学变量（如年龄、婚姻状况、怀孕次数、首次怀孕年龄）与分泌可测量量乳腺液的能力之间存在关联。此外，在个体受试者中，血清中的催乳素和雌激素水平与乳腺液中的相应水平之间似乎没有相关性。然而，乳腺液催乳素水平中位数约为相应血清值的两倍，乳腺液雌激素水平中位数约为相应血清值的六倍。看来乳腺导管上皮细胞能够主动将类固醇和多肽激素转运过浓度屏障。建议对乳腺癌高风险和低风险人群的乳腺液中的激素和潜在致癌物进行进一步的代谢流行病学研究。
