神经胶质细胞和神经胶质瘤细胞系中的干扰素产生
Interferon production in glia and glioma cell lines.
作者信息
Larsson I, Landström L E, Larner E, Lundgren E, Miörner H, Strannegård L
出版信息
Infect Immun. 1978 Dec;22(3):786-9. doi: 10.1128/iai.22.3.786-789.1978.
Abstract
Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.
摘要
干扰素（IF）在神经胶质细胞和胶质瘤细胞系中产生，其效价与人成纤维细胞产生的相当。它可被仙台病毒和聚肌苷酸：聚胞苷酸诱导。“超诱导”使IF效价提高多达500倍。通过热处理实验、在异源细胞系中检测抗病毒活性以及用特异性抗血清中和实验表明，该IF似乎属于成纤维细胞型。由于利用胶质瘤细胞系可轻松产生大量IF，因此这类细胞可能适合大规模生产IF。
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本文引用的文献
1
Antitumor effects of interferon preparations in mice.干扰素制剂对小鼠的抗肿瘤作用。
J Natl Cancer Inst. 1970 Aug;45(2):365-76.
2
Interferon and interferon inducers in the treatment of malignancies.干扰素及干扰素诱导剂在恶性肿瘤治疗中的应用
Arch Intern Med. 1970 Jul;126(1):78-83.
3
Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin.干扰素与细胞分裂。IX. 抗干扰素的L1210细胞：特性与起源。
J Natl Cancer Inst. 1974 Feb;52(2):553-9. doi: 10.1093/jnci/52.2.553.
4
Production of high-titered interferon in cultures of human diploid cells.在人二倍体细胞培养物中产生高滴度干扰素。
Antimicrob Agents Chemother. 1972 Dec;2(6):476-84. doi: 10.1128/AAC.2.6.476.
5
Human leukocyte interferon: production, purification, stability, and animal experiments.人白细胞干扰素：生产、纯化、稳定性及动物实验
In Vitro Monogr. 1974(3):35-8.
6
Pronounced antiviral activity of human interferon on bovine and porcine cells.人干扰素对牛和猪细胞具有显著的抗病毒活性。
Nature. 1974 Oct 11;251(5475):543-5. doi: 10.1038/251543a0.
7
Long term culture of normal and neoplastic human glia.正常和肿瘤性人类神经胶质细胞的长期培养。
Acta Pathol Microbiol Scand. 1968;74(4):465-86. doi: 10.1111/j.1699-0463.1968.tb03502.x.
8
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Proc Natl Acad Sci U S A. 1973 Oct;70(10):2789-93. doi: 10.1073/pnas.70.10.2789.
9
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J Immunol. 1975 Feb;114(2 Pt 1):640-4.
10
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