神经胶质细胞和神经胶质瘤细胞系中的干扰素产生
Interferon production in glia and glioma cell lines.
作者信息
Larsson I, Landström L E, Larner E, Lundgren E, Miörner H, Strannegård L
出版信息
Infect Immun. 1978 Dec;22(3):786-9. doi: 10.1128/iai.22.3.786-789.1978.
Abstract
Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.
摘要
干扰素（IF）在神经胶质细胞和胶质瘤细胞系中产生，其效价与人成纤维细胞产生的相当。它可被仙台病毒和聚肌苷酸：聚胞苷酸诱导。“超诱导”使IF效价提高多达500倍。通过热处理实验、在异源细胞系中检测抗病毒活性以及用特异性抗血清中和实验表明，该IF似乎属于成纤维细胞型。由于利用胶质瘤细胞系可轻松产生大量IF，因此这类细胞可能适合大规模生产IF。
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