细菌产生河豚毒素的再研究。
Reexamination of tetrodotoxin production by bacteria.
作者信息
Matsumura K
机构信息
Yamaguchi Prefectural Research Institute of Health, Japan.
出版信息
Appl Environ Microbiol. 1995 Sep;61(9):3468-70. doi: 10.1128/aem.61.9.3468-3470.1995.
Abstract
Vibrio alginolyticus has been reported as a good producer of tetrodotoxin (TTX), but the toxin extracted from this bacterium did not react to the monoclonal antibody against TTX. Surprisingly, chromatographic analyses detected high TTX peaks for polypeptone and yeast extracts used as medium materials, which were, as expected, all negative by the mouse bioassay. These results may require us to revise the bacterial production of TTX.
摘要
溶藻弧菌已被报道为河豚毒素（TTX）的良好生产者，但从这种细菌中提取的毒素与抗TTX单克隆抗体没有反应。令人惊讶的是，色谱分析检测到用作培养基材料的蛋白胨和酵母提取物中有高TTX峰，正如预期的那样，这些提取物经小鼠生物测定均为阴性。这些结果可能要求我们修正TTX的细菌生产情况。
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