细菌SOS功能诱导中的早期事件及机制：体内噬菌体阻遏物失活过程分析
Early events and mechanisms in the induction of bacterial SOS functions: analysis of the phage repressor inactivation process in vivo.
作者信息
Smith C L, Oishi M
出版信息
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1657-61. doi: 10.1073/pnas.75.4.1657.
Abstract
Different inducing agents and treatments produced distinctly different kinetic patterns of inactivation of prophage repressor molecules. The different patterns were related to differences in the initial altered states of DNA that were produced. The timing of appearance of DNA degradation was correlated with the time needed for repressor inactivation. These characteristics suggest that all the inducing treatments lead to the formation of a final predegradative DNA structure(s) (probably involving scissions) that is acted on by specific DNases, including the recBC DNase, to produce the signals for the induction of prophage.
摘要
不同的诱导剂和处理方式产生了明显不同的原噬菌体阻遏物分子失活动力学模式。这些不同的模式与所产生的DNA初始改变状态的差异有关。DNA降解出现的时间与阻遏物失活所需的时间相关。这些特征表明，所有的诱导处理都会导致形成一种最终的预降解DNA结构（可能涉及断裂），该结构会被包括recBC核酸酶在内的特定核酸酶作用，以产生诱导原噬菌体的信号。
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Early events and mechanisms in the induction of bacterial SOS functions: analysis of the phage repressor inactivation process in vivo.细菌SOS功能诱导中的早期事件及机制：体内噬菌体阻遏物失活过程分析
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1657-61. doi: 10.1073/pnas.75.4.1657.
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