Wu S, Craig R M
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Dig Dis Sci. 1995 Apr;40(4):843-52. doi: 10.1007/BF02064990.
The value of intense nutritional support in inflammatory bowel disease is still debated. Claims have been made that total enteral nutrition is as effective as total parental nutrition. In this review, the use of parenteral and enteral nutritional support as primary therapy in patients with inflammatory bowel disease has been critically evaluated. Most studies have been uncontrolled and nonrandomized with short-term follow-up. The literature does suggest, however, that intense nutritional support may have an adjunctive role to drug therapy in achieving remission in Crohn's disease, especially in corticosteroid-refractory patients. Nutritional support has a lesser role in chronic ulcerative colitis, except for assistance in pre- and postoperative management. The data do not support one variety of nutritional support over another, although enteral support should be used if possible, as it is less costly and potentially less complicated.
强化营养支持在炎症性肠病中的价值仍存在争议。有人声称肠内营养与肠外营养同样有效。在这篇综述中,对肠外和肠内营养支持作为炎症性肠病患者的主要治疗方法的应用进行了严格评估。大多数研究是非对照、非随机的,且随访时间较短。然而,文献确实表明,强化营养支持在克罗恩病实现缓解方面可能对药物治疗起到辅助作用,尤其是在对皮质类固醇难治的患者中。营养支持在慢性溃疡性结肠炎中的作用较小,除了在术前和术后管理方面提供帮助。尽管如果可能应使用肠内支持,因为其成本较低且潜在并发症较少,但现有数据并不支持一种营养支持方式优于另一种。