Faizi S, Siddiqui B S, Saleem R, Siddiqui S, Aftab K, Gilani A H
H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
J Nat Prod. 1994 Sep;57(9):1256-61. doi: 10.1021/np50111a011.
Bioassay-guided analysis of an EtOH extract of Moringa oleifera leaves showing hypotensive activity led to the isolation of two nitrile glycosides, niazirin [1] and niazirinin [2], and three mustard oil glycosides, 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy)benzyl]isothiocyanate [4], niaziminin A, and niaziminin B. Glycoside 2 is a new compound. Niaziminins A and B have previously been obtained from the left extract as a mixture, while compound 4 is new from this source. Structural determination was accomplished by means of spectroscopic methods including appropriate 2D nmr experiments and chemical reactions. This is the first report of the isolation of nitriles, an isothiocyanate, and thiocarbamates from the same plant species. Isothiocyanate 4 and the thiocarbamate glycosides niaziminin A and B showed hypotensive activity while nitrile glycosides 1 and 2 were found to be inactive in this regard.
对显示有降压活性的辣木叶乙醇提取物进行生物测定导向分析，从中分离出两种腈苷，即尼亚齐林[1]和尼亚齐林宁[2]，以及三种芥子油苷，4-[(4'-O-乙酰基-α-L-鼠李糖氧基)苄基]异硫氰酸酯[4]、尼亚齐米宁A和尼亚齐米宁B。苷2是一种新化合物。尼亚齐米宁A和B以前是从左提取物中作为混合物获得的，而化合物4是首次从该来源获得。通过包括适当的二维核磁共振实验和化学反应在内的光谱方法完成了结构测定。这是首次从同一植物物种中分离出腈、异硫氰酸酯和硫代氨基甲酸盐的报告。异硫氰酸酯4和硫代氨基甲酸盐苷尼亚齐米宁A和B显示出降压活性，而腈苷1和2在这方面没有活性。
