静脉注射乳酸钠可降低人体血浆中γ-氨基丁酸（GABA）的水平。

Intravenous sodium lactate decreases plasma GABA levels in man.

作者信息

Balon R, Petty F, Yeragani V K, Kramer G L, Pohl R

机构信息

Department of Psychiatry, Wayne State University School of Medicine and Lafayette Clinic, Detroit, MI 48207.

出版信息

Psychopharmacology (Berl). 1993;110(3):368-70. doi: 10.1007/BF02251295.

DOI:10.1007/BF02251295

PMID:7831433

Abstract

Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter, may play an important role in anxiety. We studied changes in plasma GABA levels in nine healthy subjects before and after infusions of sodium lactate and dextrose. Plasma GABA significantly decreased during infusions of sodium lactate (109.3 +/- 4.4 versus 91.6 +/- 5.1 pmol/ml; P = 0.0001) but not during infusions of dextrose.

摘要

γ-氨基丁酸（GABA）是一种抑制性神经递质，可能在焦虑中发挥重要作用。我们研究了9名健康受试者在输注乳酸钠和葡萄糖前后血浆GABA水平的变化。输注乳酸钠期间血浆GABA显著降低（109.3±4.4对91.6±5.1 pmol/ml；P = 0.0001），但输注葡萄糖期间未降低。