Delfino R J, Becklake M R, Hanley J A
Department of Epidemiology & Biostatistics, McGill University, Montreal, Quebec, Canada.
Environ Res. 1994 Oct;67(1):1-19. doi: 10.1006/enrs.1994.1061.
The relationship between the number of daily urgent hospital admissions for respiratory illnesses (31 hospitals) and ambient air pollution in Montreal, Canada, was investigated for warm periods between 1984 and 1988. Air pollutants included 1-hr and 8-hr maximum ozone, estimated particulate matter < or = 10 microns in aerometric diameter (PM10), and estimated sulfate (SO4(2-) fraction of PM10. Regression analyses controlled for seasonal and day-of-week trends, autocorrelation, temperature, and relative humidity. For July and August periods, there was a statistically significant (P < 0.01) univariate relationship of all respiratory admissions to 8-hr maximum ozone, which became nonsignificant when coregressed with temperature. Levels of ozone which never exceeded the U.S. National Ambient Air Quality Standard (NAAQS) of 120 ppb and high intercorrelations between ozone, particulates, and temperature may explain this finding. Asthma admissions in the May-October periods increased by 2.7% over mean levels for each 12 micrograms/m3 increase in PM10 levels 3 days prior to the admission day (95% confidence interval, 0.7 to 4.8%). In the July and August periods, hospital admissions for respiratory illnesses excluding asthma were 9.6% higher (95% confidence interval, 0.5 to 18.7%) when estimated SO4(2-) had exceeded 8.1 micrograms/m3 4 days prior to the admission day compared to days when SO4(2-) was at or below this level. There were no significant (P < 0.05) associations of a reference group of nonrespiratory admissions to air pollution after controlling for weather. The above results were found despite levels of PM10 which never exceeded the NAAQS of 150 micrograms/m3. The associations found are relevant to public health, since hospital admissions are expected to be accompanied by considerably more frequent occurrences of less serious outcomes. The present findings suggest that particulate air pollution during photochemically active periods is related to respiratory morbidity in Montreal.
1984年至1988年温暖时期,对加拿大蒙特利尔31家医院每日因呼吸系统疾病而急诊入院的人数与环境空气污染之间的关系进行了调查。空气污染物包括1小时和8小时最大臭氧浓度、估算的空气动力学直径小于或等于10微米的颗粒物(PM10)以及估算的硫酸盐(PM10中的SO4(2-)部分)。回归分析对季节和星期几的趋势、自相关、温度和相对湿度进行了控制。在7月和8月期间,所有呼吸系统疾病入院人数与8小时最大臭氧浓度之间存在统计学显著(P < 0.01)的单变量关系,当与温度进行共回归时这种关系变得不显著。从未超过美国国家环境空气质量标准(NAAQS)120 ppb的臭氧水平以及臭氧、颗粒物和温度之间的高度相互关联可能解释了这一发现。在5月至10月期间,入院前3天PM10水平每增加12微克/立方米,哮喘入院人数比平均水平增加2.7%(95%置信区间,0.7%至4.8%)。在7月和8月期间,与入院前4天SO4(2-)处于或低于8.1微克/立方米的日子相比,当入院前4天估算的SO4(2-)超过8.1微克/立方米时,排除哮喘的呼吸系统疾病入院人数高9.6%(95%置信区间,0.5%至18.7%)。在控制天气因素后,非呼吸系统疾病入院人数的参考组与空气污染之间没有显著(P < 0.05)关联。尽管PM10水平从未超过150微克/立方米的NAAQS,但仍发现了上述结果。所发现的关联与公共卫生相关,因为预计住院伴随着更频繁出现的不太严重的后果。目前的研究结果表明,光化学活跃时期的颗粒物空气污染与蒙特利尔的呼吸系统发病率有关。