耐受性小鼠免疫记忆的产生。
Generation of immunological memory in tolerant mice.
作者信息
Tite J P, Playfair J H
出版信息
Immunology. 1978 Jun;34(6):1097-107.
Adult mice pretreated with dinitrophenylated isologous gamma globulins respond very poorly to the hapten presented in immunogenic form. However, the responses of such tolerized and primed animals, or the spleen cells from such mice on adoptive transfer, to small doses of soluble antigen revealed normal secondary responsiveness in terms of size of response, relative affinities of the antibodies produced and antigenic sensitivity. In contrast, mice tolerized in early life and subsequently primed showed diminished responsiveness to secondary challenge, both in the original animals and on adoptive transfer. In this instance cells producing high affinity antibodies seemed to be preferentially deleted.
用二硝基苯基化的同源γ球蛋白预处理的成年小鼠，对以免疫原形式呈现的半抗原反应非常差。然而，这种耐受并致敏的动物，或此类小鼠的脾细胞在过继转移后，对小剂量可溶性抗原的反应，在反应大小、产生的抗体的相对亲和力和抗原敏感性方面显示出正常的二次反应性。相比之下，早年耐受并随后致敏的小鼠，在原动物和过继转移时，对二次攻击的反应性都降低。在这种情况下，产生高亲和力抗体的细胞似乎被优先清除。
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