吡咯吲哚霉素，由 rugosporus 链霉菌 sp. LL-42D005 产生的新型抗生素。I. 分离与结构测定。
Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.
作者信息
Ding W, Williams D R, Northcote P, Siegel M M, Tsao R, Ashcroft J, Morton G O, Alluri M, Abbanat D, Maiese W M
机构信息
Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.
出版信息
J Antibiot (Tokyo). 1994 Nov;47(11):1250-7. doi: 10.7164/antibiotics.47.1250.
Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.
吡咯吲哚霉素A和B是从 rugosporus链霉菌菌株LL-42D005的发酵产物中分离得到的。吡咯吲哚霉素对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌具有强大的抗菌活性。它们的结构已通过1D和2D核磁共振、质谱分析和化学降解得以确定。吡咯吲哚霉素是首批含有高度不饱和吡咯吲哚部分的天然产物。
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