氨基糖苷类抗生素的酶促修饰：一种来自铜绿假单胞菌分离株的新型6'-N-乙酰化酶。
Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
作者信息
Haas M, Biddlecome S, Davies J, Luce C E, Daniels P J
出版信息
Antimicrob Agents Chemother. 1976 Jun;9(6):945-50. doi: 10.1128/AAC.9.6.945.
Abstract
We describe an aminoglycoside 6'-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.
摘要
我们描述了一种从铜绿假单胞菌中分离出的氨基糖苷6'-N-乙酰基转移酶，该酶表现出一种新的底物谱，其特征是对丁胺卡那霉素和阿米卡星的活性显著降低。
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本文引用的文献
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Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的酶促乙酰化作用。
Biochemistry. 1971 May 11;10(10):1787-96. doi: 10.1021/bi00786a009.
2
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.由卡那霉素抗性大肠杆菌无细胞系统使卡那霉素失活后的分离及结构研究
J Antibiot (Tokyo). 1967 Jul;20(3):136-41.
3
The structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensis.紫苏霉素的结构，一种来自英氏小单孢菌的新型不饱和氨基环醇抗生素。
J Org Chem. 1974 May 31;39(11):1451-7. doi: 10.1021/jo00924a001.
4
Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production.卡那霉素链霉菌利用碳源和氮源生产卡那霉素的研究。
Antimicrob Agents Chemother. 1973 Jul;4(1):6-10. doi: 10.1128/AAC.4.1.6.
5
[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].[由一种同工酶，卡那霉素乙酰转移酶诱导产生的对氨基糖苷类抗生素的耐药性]
Biochimie. 1974;56(6-7):893-7. doi: 10.1016/s0300-9084(74)80512-2.
6
Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.肺炎克雷伯菌和阴沟肠杆菌中与妥布霉素酶促乙酰化相关的可转移的妥布霉素耐药性。
Antimicrob Agents Chemother. 1974 Oct;6(4):492-7. doi: 10.1128/AAC.6.4.492.
7
R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase.R因子介导的铜绿假单胞菌对氨基糖苷类抗生素的耐药性：一种新的氨基糖苷6'-N-乙酰基转移酶
Antimicrob Agents Chemother. 1975 May;7(5):494-9. doi: 10.1128/AAC.7.5.494.
8
Aminoglycoside-modifying enzymes.氨基糖苷类修饰酶
Methods Enzymol. 1975;43:611-28. doi: 10.1016/0076-6879(75)43124-x.
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