对氨基糖苷类药物表现出特异性超敏反应的铜绿假单胞菌突变体。
Mutants of Pseudomonas aeruginosa that show specific hypersensitivity to aminoglycosides.
作者信息
Mills B J, Holloway B W
出版信息
Antimicrob Agents Chemother. 1976 Sep;10(3):411-6. doi: 10.1128/AAC.10.3.411.
Abstract
A class of mutants in Pseudomonas aeruginosa have been found that are tolerant to aeruginocin 41 and also hypersensitive to aminoglycosides. They do not show any changes in susceptibility to a wide range of other toxic agents, including antibiotics and surfactants. This tol locus, tolA, has been mapped at 10 min from the FP2 origin and linked to carA (carbamyl phosphate synthetase) by transduction and conjugation. By selecting for revertants of the hypersensitivity phenotype, revertants to tol(+) were found, indicating that it is the tolA locus that is responsible for this specific hypersensitivity. The results indicate that a specific mechanism exists for the intrinsic resistance of P. aeruginosa to aminoglycosides.
摘要
已发现铜绿假单胞菌中的一类突变体对绿脓菌素41具有耐受性，且对氨基糖苷类药物高度敏感。它们对包括抗生素和表面活性剂在内的多种其他有毒物质的敏感性没有任何变化。这个tol位点，即tolA，已被定位在距FP2原点10分钟处，并通过转导和接合与carA（氨甲酰磷酸合成酶）相连。通过选择超敏表型的回复突变体，发现了tol(+)的回复突变体，这表明正是tolA位点导致了这种特定的超敏反应。结果表明，铜绿假单胞菌对氨基糖苷类药物的固有抗性存在一种特定机制。
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