Costelli P, Carbó N, Tessitore L, Bagby G J, Lopez-Soriano F J, Argilés J M, Baccino F M
Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.
J Clin Invest. 1993 Dec;92(6):2783-9. doi: 10.1172/JCI116897.
Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.
携带吉田AH - 130腹水肝癌的大鼠，其腓肠肌、心脏和肝脏中的蛋白质降解分数率增强，而蛋白质合成分数率与未患肿瘤的大鼠相似。这种高分解代谢模式与激素稳态的明显紊乱以及循环中肿瘤坏死因子的存在有关。与接受非免疫山羊IgG的荷瘤大鼠相比，每天给荷瘤大鼠注射山羊抗小鼠TNF IgG可降低骨骼肌、心脏和肝脏中的蛋白质降解率。抗TNF治疗在减轻胰岛素和皮质酮稳态的早期紊乱方面也有效。尽管这些结果表明肿瘤坏死因子在介导肿瘤生长引起的蛋白质周转和激素水平变化中起重要作用，但这种治疗无法防止体重减轻，这意味着还涉及其他介质或与肿瘤相关的事件。
