照顾艾滋病患者的医护人员的卡氏肺孢子虫抗体血清滴度。
Serum titres of Pneumocystis carinii antibody in health care workers caring for patients with AIDS.
作者信息
Leigh T R, Millett M J, Jameson B, Collins J V
机构信息
Department of Respiratory Medicine, Chelsea and Westminister Hospital, London.
出版信息
Thorax. 1993 Jun;48(6):619-21. doi: 10.1136/thx.48.6.619.
BACKGROUND
Pneumocystis carinii pneumonia was thought to occur from reactivation of latent infection, but recent studies with the polymerase chain reaction have failed to detect P carinii in normal subjects. If pneumocystis pneumonia is therefore caused by new infection the source and mode of transmission of P carinii remains unknown.
METHODS
Natural exposure to P carinii was detected by measuring antibodies by indirect immunofluorescence in 24 health care workers working continuously with patients with AIDS and 24 control health care workers exclusively treating elderly patients.
RESULTS
P carinii antibody titres were significantly higher in the health care workers exposed to AIDS than in the control group (median titre 1:32 v 1:16 respectively). Three control subjects had no antibodies compared with none of the subjects exposed to AIDS, and 10 of the 12 highest titres came from the exposed group.
CONCLUSIONS
Raised P carinii antibody titres in health care workers caring for patients with AIDS suggest that patients infected with HIV may be a potentially infectious source of P carinii for susceptible subjects.
背景
卡氏肺孢子虫肺炎曾被认为是由潜伏感染的重新激活所致，但近期利用聚合酶链反应进行的研究未能在正常受试者中检测到卡氏肺孢子虫。因此，如果肺孢子虫肺炎是由新感染引起的，那么卡氏肺孢子虫的来源和传播方式仍不清楚。
方法
通过间接免疫荧光法检测抗体，以检测24名持续照料艾滋病患者的医护人员及24名专门诊治老年患者的对照医护人员对卡氏肺孢子虫的自然暴露情况。
结果
接触艾滋病患者的医护人员的卡氏肺孢子虫抗体滴度显著高于对照组（中位数滴度分别为1:32和1:16）。3名对照受试者无抗体，而接触艾滋病患者的受试者均有抗体，且12个最高滴度中有10个来自接触组。
结论
照料艾滋病患者的医护人员中卡氏肺孢子虫抗体滴度升高表明，感染HIV的患者可能是卡氏肺孢子虫对易感人群的一个潜在传染源。
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