生殖器病变中单纯疱疹病毒的检测：一项使用抗原检测（HerpChek）和培养法的比较研究。
Herpes simplex virus detection from genital lesions: a comparative study using antigen detection (HerpChek) and culture.
作者信息
Cone R W, Swenson P D, Hobson A C, Remington M, Corey L
机构信息
Department of Laboratory Medicine, University of Washington, Seattle 98195.
出版信息
J Clin Microbiol. 1993 Jul;31(7):1774-6. doi: 10.1128/jcm.31.7.1774-1776.1993.
Abstract
The sensitivity of a rapid enzyme immunoassay test (HerpChek Direct Herpes Simplex Virus Antigen Test [DuPont Medical Products, Wilmington, Del.]) for the detection of herpes simplex virus (HSV) antigens in patient specimens was compared with HSV culture. HerpChek positivity for HSV occurred with 179 (65%) of 275 lesion specimens, whereas culture for HSV was positive for 145 (53%) lesions (P = 0.002). HerpChek was twice as sensitive as culture for the detection of HSV in late-stage lesions and was equivalent to culture for the detection of HSV in early lesions. We conclude that HerpChek provides greater sensitivity than culture for HSV detection in late-stage genital lesions.
摘要
将一种快速酶免疫测定试验（HerpChek直接单纯疱疹病毒抗原检测[杜邦医疗产品公司，特拉华州威尔明顿]）用于检测患者标本中单纯疱疹病毒（HSV）抗原的敏感性与HSV培养法进行了比较。275份皮损标本中有179份（65%）的HerpChek检测HSV呈阳性，而HSV培养法检测出145份（53%）皮损呈阳性（P = 0.002）。在检测晚期皮损中的HSV时，HerpChek的敏感性是培养法的两倍，在检测早期皮损中的HSV时，其敏感性与培养法相当。我们得出结论，在检测晚期生殖器皮损中的HSV时，HerpChek比培养法具有更高的敏感性。
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