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[胰腺囊性肿瘤]

[Cystic pancreatic tumors].

作者信息

Schneider C, Reck T, Greskötter K R, Köckerling F, Gall F P

机构信息

Chirurgische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.

出版信息

Langenbecks Arch Chir. 1993;378(5):281-7. doi: 10.1007/BF00183965.

Abstract

Before 1978, where cystic tumors of the pancreas were concerned, pathologists only differentiated between cystic adenomas and cystadenocarcinomas. Recently, however, further tumor entities have been introduced. We now differentiate between the generally benign serous cystic adenoma, the potentially malignant mucinous cystadenoma, the possibly malignant papillary cystic tumor, and the always malignant mucinous cystadenocarcinoma. Other rare tumors include the solid cystic acinous-cell tumor, the cystic islet tumor, and mucinous ductal hyperplasia. Because of their slow growth and primary displacement nature, all of these tumors can usually be detected only after they have attained considerable size. Computed tomography (CT), sonography and endoscopic retrograde cholangiopancreatography (ERCP) have an established role in diagnosis. With these methods, as a rule, it is possible to identify pseudocysts; however, differentiation between the individual tumor types is almost impossible. In our study from 1979 to 1990, we observed ten cases of serous cystic adenomas, nine cystadenocarcinomas, and four malignant papillary-cystic tumors. Of these, nine of the ten serous cystic adenomas, four of the five mucinous cystadenomas, all four papillary-cystic tumors, and five of the nine cystadenocarcinomas were curatively resected. All patients with curatively resected adenomas and one patient with an R1-resected cystic adenoma remained free of recurrence throughout the follow-up period. One 86-year-old female patient in whom a serous cystic adenoma was histologically determined still has no symptoms 8 years after diagnosis despite slow tumor progression. Two of the five patients in whom a cystadenocarcinoma was curatively resected died postoperatively; a third patient died of tumor recurrence 4 months following resection.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1978年以前,对于胰腺囊性肿瘤,病理学家仅区分囊性腺瘤和囊腺癌。然而,近年来又引入了其他肿瘤类型。现在我们将通常为良性的浆液性囊性腺瘤、潜在恶性的黏液性囊性腺瘤、可能为恶性的乳头状囊性肿瘤以及总是恶性的黏液性囊腺癌区分开来。其他罕见肿瘤包括实性囊性腺泡细胞瘤、囊性胰岛细胞瘤和黏液性导管增生。由于这些肿瘤生长缓慢且具有原发性移位的特点,通常只有在它们长得相当大之后才能被发现。计算机断层扫描(CT)、超声检查和内镜逆行胰胆管造影(ERCP)在诊断中发挥着既定作用。通常,通过这些方法可以识别假性囊肿;然而,几乎不可能区分各种肿瘤类型。在我们1979年至1990年的研究中,我们观察到10例浆液性囊性腺瘤、9例囊腺癌和4例恶性乳头状囊性肿瘤。其中,10例浆液性囊性腺瘤中的9例、5例黏液性囊性腺瘤中的4例、所有4例乳头状囊性肿瘤以及9例囊腺癌中的5例均接受了根治性切除。所有接受根治性切除腺瘤的患者以及1例接受R1切除的囊性腺瘤患者在整个随访期间均未复发。一名86岁女性患者经组织学确诊为浆液性囊性腺瘤,尽管肿瘤进展缓慢,但诊断8年后仍无症状。5例接受根治性切除囊腺癌的患者中有2例术后死亡;第3例患者在切除术后4个月死于肿瘤复发。(摘要截选至250词)

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