Teare M D, Santibáñez-Koref M F, Wallace S A, White G R, Evans D G, Burnell L D, Harris M, Howell A, Birch J M
Cancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.
Am J Hum Genet. 1993 Apr;52(4):786-8.
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
通过使用五个标记，对七个乳腺癌家族进行检测，以寻找与17q12 - q21区域某位点的连锁证据。这些家族是一大系列家族性乳腺癌中的一个子集；选择这七个家族是因为在信息丰富的成员身上可获得组成性DNA，这些DNA要么来自临床样本，要么从石蜡块中提取。报告了两点连锁值。在θ = 0时，标记NM23获得的最大连锁值为0.8824。其本身显然不显著；然而，结合现有报告的证据来看，它为与该区域的连锁提供了支持。
