Newsome W H, Davies D
Food Research Division, Bureau of Chemical Safety Food Directorate, Health Canada, Ottawa, Canada.
Chemosphere. 1996 Aug;33(3):559-65. doi: 10.1016/0045-6535(96)00199-3.
Chlorinated biphenyl methylsulfones and biphenylols were determined in samples of human milk from Canadian donors. Fifty samples containing an average of 10.8 ng g-1 (w/w) of total PCBs were found to contain an average of 68 pg g-1 of chlorinated biphenyl methylsulfone. The major congeners were 3-methylsulfonyl-2,2',4',5,5',-pentachlorobiphenyl, 4-methylsulfonyl-2,2',3',4',5,-pentachlorobiphenyl and 4-methylsulfonyl-2,2',3',5,5',6'-hexachlorobiphenyl. Twelve of these samples were analyzed for five chlorinated biphenylols and the 4-methoxy-2,2',3,4',5,5',6-heptachlorobiphenylol congener was detected in all at an average concentration of 1.9 pg g-1. The chlorinated biphenylols appear to be minor residual metabolites in human milk from the general population. The fifty samples with an average of 8.4 ng g-1 of p,p'-DDE also contained an average of 16.5 pg g-1 of the corresponding methylsulfone. Both the total PCB methylsulfone and p,p' DDE methylsulfone were correlated with total PCB and p,p' DDE contents, respectively.
对来自加拿大捐赠者的母乳样本中的氯化联苯甲基砜和联苯醇进行了测定。发现50个平均总多氯联苯含量为10.8 ng g-1（w/w）的样本中，平均含有68 pg g-1的氯化联苯甲基砜。主要同系物为3-甲基磺酰基-2,2',4',5,5'-五氯联苯、4-甲基磺酰基-2,2',3',4',5-五氯联苯和4-甲基磺酰基-2,2',3',5,5',6'-六氯联苯。对其中12个样本分析了5种氯化联苯醇，所有样本均检测到4-甲氧基-2,2',3,4',5,5',6-七氯联苯醇同系物，平均浓度为1.9 pg g-1。氯化联苯醇似乎是普通人群母乳中的次要残留代谢物。50个平均p,p'-滴滴伊含量为8.4 ng g-1的样本中，还平均含有16.5 pg g-1的相应甲基砜。总多氯联苯甲基砜和p,p'-滴滴伊甲基砜分别与总多氯联苯和p,p'-滴滴伊含量相关。
