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1972 - 1992年瑞典母乳中多氯联苯和滴滴涕的甲基磺酰代谢物

Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992.

作者信息

Norén K, Lundén A, Pettersson E, Bergman A

机构信息

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

出版信息

Environ Health Perspect. 1996 Jul;104(7):766-72. doi: 10.1289/ehp.104-1469405.

DOI:10.1289/ehp.104-1469405
PMID:8841763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1469405/
Abstract

A multicomponent method used for analysis of organochlorine pesticides, polychlorinated biphenyls (PCBs), naphthalenes, dibenzo-p-dioxins, and dibenzofurans was adapted for the analysis of methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and of p,p'-DDE (MeSO2-DDE) in human milk. The extraction and initial purification was made by liquid-gel partitioning. Additional purification and separation steps were achieved by adsorption and gel permeation chromatography. The mean recoveries of 23 MeSO2-CBs and MeSO2-DDE standards, added to the milk before extraction, were 80-97%. Human milk sampled in Stockholm during 1972, 1976, 1980, 1984/85, 1990, 1991, and 1992 was analyzed by GC-MS. During the time course studied, the concentrations of MeSO2-CBs decreased from approximately 9 to 2 ng/g lipids and of MeSO2-DDE from 5 to 0.4 ng/g lipids. The concentrations of MeSO2-CBs and MeSO2-DDE correlated to the levels of total PCB and p,p'-DDE, respectively. 3-MeSO2-DDE was the major isomer of the aryl methyl sulfones studied in the milk. PCB methyl sulfones with five and six chlorine atoms in the molecule were predominant among the PCB methyl sulfones Generally, the concentrations of 4-MeSO2-CBs were higher than the corresponding 3-MeSO2-CB compound. The major MeSO2-CBs in the milk were 4-MeSO2-2,5,2',3',4'-pentaCB (4-87) and 4-MeSO2-2,3,6,2',4',5'-hexaCB (4-149).

摘要

一种用于分析有机氯农药、多氯联苯（PCBs）、萘、二苯并 - p - 二恶英和二苯并呋喃的多组分方法，被应用于分析人乳中氯化联苯（MeSO2 - CBs）和p,p'-二氯二苯二氯乙烯（MeSO2 - DDE）的甲基磺酰代谢物。通过液 - 凝胶分配进行萃取和初步纯化。通过吸附和凝胶渗透色谱法实现进一步的纯化和分离步骤。在萃取前添加到牛奶中的23种MeSO2 - CBs和MeSO2 - DDE标准品的平均回收率为80 - 97%。对1972年、1976年、1980年、1984/85年、1990年、1991年和1992年在斯德哥尔摩采集的人乳进行了气相色谱 - 质谱分析。在所研究的时间段内，MeSO2 - CBs的浓度从约9 ng/g脂质降至2 ng/g脂质，MeSO2 - DDE的浓度从5 ng/g脂质降至0.4 ng/g脂质。MeSO2 - CBs和MeSO2 - DDE的浓度分别与总PCB和p,p'-DDE的水平相关。3 - MeSO2 - DDE是在所研究的牛奶中的芳基甲基砜的主要异构体。分子中含有五个和六个氯原子的PCB甲基砜在PCB甲基砜中占主导地位。一般来说，4 - MeSO2 - CBs的浓度高于相应的3 - MeSO2 - CB化合物。牛奶中主要的MeSO2 - CBs是4 - MeSO2 - 2,5,2',3',4'-五氯联苯（4 - 87）和4 - MeSO2 - 2,3,6,2',4',5'-六氯联苯（4 - 149）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/3a4747e76c26/envhper00338-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/4ddb740df8b1/envhper00338-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/20c6b2ea7af4/envhper00338-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/e88245cb27ef/envhper00338-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/b62fb8ec403b/envhper00338-0098-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/5ffd92e6cc6c/envhper00338-0098-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/3a4747e76c26/envhper00338-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/4ddb740df8b1/envhper00338-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/20c6b2ea7af4/envhper00338-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/e88245cb27ef/envhper00338-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/b62fb8ec403b/envhper00338-0098-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/5ffd92e6cc6c/envhper00338-0098-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9a/1469405/3a4747e76c26/envhper00338-0099-a.jpg

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