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1
Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366.与VanB型屎肠球菌D366中万古霉素耐药性表达相关的青霉素耐受性及脂磷壁酸修饰
Antimicrob Agents Chemother. 1996 Jan;40(1):257-9. doi: 10.1128/AAC.40.1.257.
2
Peptidoglycan structure of Enterococcus faecium expressing vancomycin resistance of the VanB type.表达VanB型万古霉素耐药性的屎肠球菌的肽聚糖结构
Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):711-5. doi: 10.1042/bj3130711.
3
Replacement of the essential penicillin-binding protein 5 by high-molecular mass PBPs may explain vancomycin-beta-lactam synergy in low-level vancomycin-resistant Enterococcus faecium D366.
FEMS Microbiol Lett. 1992 Feb 1;70(1):79-84. doi: 10.1016/0378-1097(92)90566-7.
4
Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics.非糖肽类抗生素诱导粪肠球菌对万古霉素耐药
FEMS Microbiol Lett. 1995 Oct 1;132(1-2):107-14. doi: 10.1111/j.1574-6968.1995.tb07819.x.
5
Constitutively vancomycin-resistant Enterococcus faecium resistant to synergistic beta-lactam combinations.对协同β-内酰胺组合耐药的固有耐万古霉素屎肠球菌。
Antimicrob Agents Chemother. 1993 Jun;37(6):1238-42. doi: 10.1128/AAC.37.6.1238.
6
Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate.一株临床耐万古霉素屎肠球菌分离株中含vanB新型转座子（Tn5382）与低亲和力青霉素结合蛋白5基因的遗传连锁及共转移
J Bacteriol. 1998 Sep;180(17):4426-34. doi: 10.1128/JB.180.17.4426-4434.1998.
7
Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium.屎肠球菌中可转移的、质粒介导的vanB型糖肽抗性
Antimicrob Agents Chemother. 1998 Apr;42(4):963-4. doi: 10.1128/AAC.42.4.963.
8
Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the vanB phenotype.在由具有vanB表型的耐万古霉素肠球菌引起的一次暴发期间，一株耐替考拉宁屎肠球菌突变株的出现。
J Clin Microbiol. 2001 Dec;39(12):4274-82. doi: 10.1128/JCM.39.12.4274-4282.2001.
9
The activity of daptomycin on Enterococcus faecium protoplasts: indirect evidence supporting a novel mode of action on lipoteichoic acid synthesis.达托霉素对屎肠球菌原生质体的活性：支持对脂磷壁酸合成作用新机制的间接证据
J Antimicrob Chemother. 1993 Feb;31(2):227-35. doi: 10.1093/jac/31.2.227.
10
Phenotypic and genotypic characterization of vancomycin-resistant Enterococcus faecium clinical isolates from two hospitals in Mexico: First detection of VanB phenotype-vanA genotype.墨西哥两家医院耐万古霉素屎肠球菌临床分离株的表型和基因型特征：首次检测到VanB表型-vanA基因型
Enferm Infecc Microbiol Clin. 2016 Aug-Sep;34(7):415-21. doi: 10.1016/j.eimc.2015.09.011. Epub 2015 Nov 14.

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Model architectures for bacterial membranes.细菌膜的模型架构。
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The cell wall-targeting antibiotic stimulon of Enterococcus faecalis.粪肠球菌的细胞壁靶向抗生素刺激子
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Characterization of the peptidoglycan of vancomycin-susceptible Enterococcus faecium.万古霉素敏感粪肠球菌肽聚糖的特性分析
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4
A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria.阴离子电荷连续体：革兰氏阳性菌中D-丙氨酰磷壁酸的结构与功能
Microbiol Mol Biol Rev. 2003 Dec;67(4):686-723. doi: 10.1128/MMBR.67.4.686-723.2003.
5
Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system.无乳链球菌中D-丙氨酰-脂磷壁酸生物合成的调控涉及一种新型双组分调控系统。
J Bacteriol. 2001 Nov;183(21):6324-34. doi: 10.1128/JB.183.21.6324-6334.2001.
6
The D-alanine residues of Staphylococcus aureus teichoic acids alter the susceptibility to vancomycin and the activity of autolytic enzymes.金黄色葡萄球菌磷壁酸的D-丙氨酸残基会改变对万古霉素的敏感性以及自溶酶的活性。
Antimicrob Agents Chemother. 2000 Oct;44(10):2845-7. doi: 10.1128/AAC.44.10.2845-2847.2000.
7
Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects intrageneric coaggregations.戈登链球菌DL1（查利斯）中负责脂磷壁酸D-丙氨酰化的基因的插入失活会影响属内共聚集。
Infect Immun. 1999 May;67(5):2464-74. doi: 10.1128/IAI.67.5.2464-2474.1999.

本文引用的文献

1
The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide-resistance proteins VanA and VanC.耐万古霉素粪肠球菌V583的vanB基因在结构上与编码D-丙氨酸：D-丙氨酸连接酶以及糖肽抗性蛋白VanA和VanC的基因相关。
Gene. 1993 Feb 14;124(1):143-4. doi: 10.1016/0378-1119(93)90779-3.
2
Molecular analysis of lipid macroamphiphiles by hydrophobic interaction chromatography, exemplified with lipoteichoic acids.通过疏水相互作用色谱法对脂质大分子两亲物进行分子分析，以脂磷壁酸为例。
Anal Biochem. 1993 Jan;208(1):49-56. doi: 10.1006/abio.1993.1007.
3
A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci.在粪肠球菌和屎肠球菌分离株中发现的一种赋予对万古霉素而非替考拉宁耐药性的基因，与肠球菌的vanB、vanA和vanC基因具有同源性。
Antimicrob Agents Chemother. 1993 Aug;37(8):1604-9. doi: 10.1128/AAC.37.8.1604.
4
Genetics and mechanisms of glycopeptide resistance in enterococci.肠球菌中糖肽类耐药的遗传学及机制
Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. doi: 10.1128/AAC.37.8.1563.
5
Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum.肽聚糖前体的修饰是低水平耐万古霉素的VANB型肠球菌D366以及天然耐糖肽类的干酪乳杆菌、戊糖片球菌、肠系膜明串珠菌和鹑鸡肠球菌的共同特征。
J Bacteriol. 1994 Apr;176(8):2398-405. doi: 10.1128/jb.176.8.2398-2405.1994.
6
Binding studies of vancomycin to the cytoplasmic peptidoglycan precursors by affinity capillary electrophoresis.通过亲和毛细管电泳研究万古霉素与细胞质肽聚糖前体的结合。
Anal Chem. 1994 Jul 15;66(14):2412-6. doi: 10.1021/ac00086a031.
7
Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.β-内酰胺类抗生素与糖肽类抗生素对耐万古霉素屎肠球菌菌株的协同作用及协同耐药性。
Antimicrob Agents Chemother. 1994 Apr;38(4):824-9. doi: 10.1128/AAC.38.4.824.
8
Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.由肠球菌转座子Tn1546介导的糖肽抗性需要产生VanX来水解D-丙氨酰-D-丙氨酸。
Mol Microbiol. 1994 Sep;13(6):1065-70. doi: 10.1111/j.1365-2958.1994.tb00497.x.
9
Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.D-丙氨酸掺入枯草芽孢杆菌的脂磷壁酸和壁磷壁酸中。基因鉴定与调控。
J Biol Chem. 1995 Jun 30;270(26):15598-606. doi: 10.1074/jbc.270.26.15598.
10
The alanine ester substitution of lipoteichoic acid (LTA) in Staphylococcus aureus.金黄色葡萄球菌中脂磷壁酸（LTA）的丙氨酸酯取代
FEBS Lett. 1980 Oct 6;119(2):224-6. doi: 10.1016/0014-5793(80)80257-2.

与VanB型屎肠球菌D366中万古霉素耐药性表达相关的青霉素耐受性及脂磷壁酸修饰

Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366.

作者信息

Gutmann L, Al-Obeid S, Billot-Klein D, Ebnet E, Fischer W

机构信息

Laboratoire de Recherche Moléculaire sur les Antibiotiques, Université Paris VI, France.

出版信息

Antimicrob Agents Chemother. 1996 Jan;40(1):257-9. doi: 10.1128/AAC.40.1.257.

DOI:10.1128/AAC.40.1.257
PMID:8787919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163096/
Abstract

Induction of vancomycin resistance in Enterococcus faecium D366, which exhibits a VanB-type resistance, as well as its constitutive expression in MT9, a derivative of D366, was associated with penicillin tolerance as shown by decreased lysis and killing of the cells. This phenomenon was linked neither to decreased expression of the different autolysins nor to their decreased lytic activity on the different cell walls. The only change observed was that almost twice the normal amount of D-alanine was attached to the lipoteichoic acid.

摘要

在表现出VanB型耐药性的屎肠球菌D366中诱导万古霉素耐药性，以及在D366的衍生物MT9中的组成型表达，与青霉素耐受性相关，如细胞裂解和杀伤减少所示。这种现象既不与不同自溶素表达的降低有关，也不与它们对不同细胞壁的裂解活性降低有关。观察到的唯一变化是，与脂磷壁酸结合的D-丙氨酸量几乎是正常量的两倍。