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本文引用的文献

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Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak.耐糖肽屎肠球菌菌株在暴发期间可改变其万古霉素基因型。
J Clin Microbiol. 1997 Nov;35(11):2966-8. doi: 10.1128/jcm.35.11.2966-2968.1997.
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Enterococcal transposon Tn5384: evolution of a composite transposon through cointegration of enterococcal and staphylococcal plasmids.肠球菌转座子Tn5384：通过肠球菌和葡萄球菌质粒的共整合形成复合转座子的进化过程。
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Mobilization of vancomycin resistance by transposon-mediated fusion of a VanA plasmid with an Enterococcus faecium sex pheromone-response plasmid.通过转座子介导的VanA质粒与粪肠球菌性信息素反应质粒融合实现万古霉素耐药性的转移
Gene. 1996 May 24;171(1):9-17. doi: 10.1016/0378-1119(96)00022-4.
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Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281.Tn1547的特性研究，Tn1547是一种复合转座子，两侧为IS16和类IS256元件，它赋予粪肠球菌BM4281对万古霉素的抗性。
Gene. 1996 Jun 12;172(1):1-8. doi: 10.1016/0378-1119(96)00110-2.
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Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.粪肠球菌V583中VanS(B)-VanR (B)双组分调节系统对VanB型万古霉素抗性基因表达的调控
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Nosocomial enterococci resistant to vancomycin--United States, 1989-1993.1989 - 1993年美国医院内耐万古霉素肠球菌
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Outbreak of multidrug-resistant Enterococcus faecium with transferable vanB class vancomycin resistance.具有可转移的vanB类万古霉素耐药性的耐多药屎肠球菌暴发。
J Clin Microbiol. 1994 May;32(5):1148-53. doi: 10.1128/jcm.32.5.1148-1153.1994.
8
IS6770, an enterococcal insertion-like sequence useful for determining the clonal relationship of clinical enterococcal isolates.IS6770，一种有助于确定临床肠球菌分离株克隆关系的肠球菌插入样序列。
J Infect Dis. 1994 Dec;170(6):1539-48. doi: 10.1093/infdis/170.6.1539.
9
Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis.粪肠球菌临床分离株中万古霉素和高水平庆大霉素耐药基因在同一质粒上的连锁关系。
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10
Detection and incidence of the tetracycline resistance determinant tet(M) in the microflora associated with adult periodontitis.与成人牙周炎相关的微生物群中四环素抗性决定因子tet(M)的检测及发生率
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屎肠球菌中可转移的、质粒介导的vanB型糖肽抗性

Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium.

作者信息

Rice L B, Carias L L, Donskey C L, Rudin S D

机构信息

Cleveland Department of Veterans Affairs Medical Center, Department of Medicine, Case Western Reserve University School of Medicine, Ohio 44106, USA.

出版信息

Antimicrob Agents Chemother. 1998 Apr;42(4):963-4. doi: 10.1128/AAC.42.4.963.

DOI:10.1128/AAC.42.4.963
PMID:9559822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105581/
Abstract

An approximately 60-kb transferable, vanB-carrying plasmid has been identified in a clinical Enterococcus faecium strain. A similar plasmid has been observed in an unrelated E. faecium strain, suggesting that plasmid transfer of vanB operons occurs in nature and plays a role in the dissemination of VanB-type resistance among strains of E. faecium.

摘要

在一株临床分离的粪肠球菌中鉴定出了一个约60 kb的可转移、携带vanB的质粒。在一株不相关的粪肠球菌中也观察到了类似的质粒，这表明vanB操纵子的质粒转移在自然界中发生，并在粪肠球菌菌株间VanB型耐药性的传播中起作用。