1980年至1990年芬兰类风湿性关节炎的发病率。
Incidence of rheumatoid arthritis in Finland during 1980-1990.
作者信息
Kaipiainen-Seppänen O, Aho K, Isomäki H, Laakso M
机构信息
Department of Medicine, Kuopio University Hospital, Finland.
出版信息
Ann Rheum Dis. 1996 Sep;55(9):608-11. doi: 10.1136/ard.55.9.608.
OBJECTIVE
To obtain information on the incidence of rheumatoid arthritis and on its recent trends in Finland.
METHODS
The study covered those subjects entitled to receive specially reimbursed medication for rheumatoid arthritis under the nationwide sickness insurance scheme in five out of 21 central hospital districts in Finland (population basis about one million adults) during three years: 1980, 1985, and 1990.
RESULTS
The annual incidence of rheumatoid arthritis in 1980 and 1985, satisfying the American Rheumatism Association 1987 classification criteria, was 39/100,000 of the population > or = 16 years of age. The combined incidence of rheumatoid factor (RF) positive arthritis and RF negative polyarthritis was 46/100,000. A decline of approximately 40% occurred in the number of RF negative rheumatoid arthritis cases in 1990 compared with the earlier years. The declining trend was statistically significant (P = 0.008).
CONCLUSION
The decline in incidence of RF negative rheumatoid arthritis in Finland may reflect changes in the environment specifically affecting the risk of RF negative disease.
目的
获取芬兰类风湿关节炎的发病率及其近期趋势的信息。
方法
该研究涵盖了芬兰21个中心医院区中的5个区（以大约100万成年人为基础），在1980年、1985年和1990年这三年中，那些有权根据全国疾病保险计划获得类风湿关节炎特殊报销药物的受试者。
结果
1980年和1985年符合美国风湿病协会1987年分类标准的类风湿关节炎年发病率为每10万≥16岁人口中有39例。类风湿因子（RF）阳性关节炎和RF阴性多关节炎的合并发病率为每10万中有46例。与早期相比，1990年RF阴性类风湿关节炎病例数下降了约40%。下降趋势具有统计学意义（P = 0.008）。
结论
芬兰RF阴性类风湿关节炎发病率的下降可能反映了环境变化对RF阴性疾病风险的特殊影响。
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