Falsey A R, McCann R M, Hall W J, Criddle M M, Formica M A, Wycoff D, Kolassa J E
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, NY.
J Am Geriatr Soc. 1997 Jun;45(6):706-11. doi: 10.1111/j.1532-5415.1997.tb01474.x.
To evaluate the incidence and impact of rhinovirus and coronavirus infections in older persons attending daycare.
Prospective descriptive study.
Three senior daycare centers in Rochester, New York.
Frail older persons and staff members of the daycare centers who developed signs or symptoms of an acute respiratory illness.
Demographic, medical, and physical findings were recorded on subjects at baseline and during respiratory illness. Nasopharyngeal specimens for viral culture as well as acute and convalescent sera for coronavirus 229E enzyme immunoassay (EIA) were obtained for all illnesses.
During the 44 months of study, 352 older persons experienced 522 illnesses. Thirty-five (7%) of 522 cultures were positive for rhinovirus and 37 (8%) of 451 serologies were positive for coronavirus 229E infection. The clinical syndromes associated with rhinovirus and coronavirus infection were similar and characterized by nasal congestion, cough, and constitutional symptoms. No patient died or was hospitalized, but approximately 50% had evidence of lower respiratory tract involvement. The average illness lasted 14 days. During the same period, 113 staff developed 338 respiratory illnesses. Eight percent were identified as coronavirus and 9% as rhinovirus. Cough, sputum production, and constitutional symptoms were significantly more common among older persons.
Rhinovirus and coronavirus 229E are common causes of moderately debilitating acute respiratory illnesses among older persons attending daycare.
评估日托机构中老年人鼻病毒和冠状病毒感染的发生率及影响。
前瞻性描述性研究。
纽约罗切斯特的三个老年日托中心。
出现急性呼吸道疾病体征或症状的体弱老年人及日托中心工作人员。
在基线和呼吸道疾病期间记录受试者的人口统计学、医学和体格检查结果。对所有疾病均采集鼻咽标本进行病毒培养，以及采集急性期和恢复期血清进行229E冠状病毒酶免疫测定（EIA）。
在44个月的研究期间，352名老年人发生了522次疾病。522次培养中有35次（7%）鼻病毒阳性，451次血清学检测中有37次（8%）229E冠状病毒感染阳性。与鼻病毒和冠状病毒感染相关的临床综合征相似，以鼻塞、咳嗽和全身症状为特征。无患者死亡或住院，但约50%有下呼吸道受累的证据。平均病程为14天。同期，113名工作人员发生了338次呼吸道疾病。8%被鉴定为冠状病毒感染，9%为鼻病毒感染。咳嗽、咳痰和全身症状在老年人中更为常见。
鼻病毒和229E冠状病毒是日托机构中老年人中度衰弱性急性呼吸道疾病的常见病因。
