Saslow S B, Thumshirn M, Camilleri M, Locke G R, Thomforde G M, Burton D D, Hanson R B
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
Dig Dis Sci. 1998 Feb;43(2):258-64. doi: 10.1023/a:1018833701109.
The effect of H. pylori infection on gastric motility and sensation is unclear. Our hypothesis is that H. pylori infection increases gastric sensation and reduces gastric accommodation and emptying. In eight H. pylori-positive and eight H. pylori-negative asymptomatic subjects, infection was proven by antral histology or culture. We evaluated: (1) gastric emptying of solids, (2) proximal gastric compliance, (3) fasting and postprandial proximal gastric tone and phasic contractions, (4) gastric sensation during balloon inflations or ingestion of cold water, and (5) abdominal vagal function. H. pylori infection was associated with lower gastric accommodation (median 75% postprandial increase in barostat balloon volume compared to fasting) when compared to the accommodation in uninfected volunteers (median 211% change from fasting). One H. pylori-positive subject had an abnormal abdominal vagal function test and her gastric accommodation response was reduced. Other motor and sensory functions in the two groups were similar. In asymptomatic volunteers, H. pylori infection and gastritis result in reduced accommodation (diastolic dysfunction) but no change in overall sensation or motor functions of the stomach.
幽门螺杆菌感染对胃动力和感觉的影响尚不清楚。我们的假设是，幽门螺杆菌感染会增加胃感觉，并降低胃容受性和排空。在8名幽门螺杆菌阳性和8名幽门螺杆菌阴性的无症状受试者中，通过胃窦组织学或培养证实感染。我们评估了：（1）固体食物的胃排空；（2）近端胃顺应性；（3）空腹和餐后近端胃张力及相性收缩；（4）气囊充气或摄入冷水期间的胃感觉；（5）腹部迷走神经功能。与未感染志愿者的胃容受性（与空腹相比，恒压器气囊容积餐后中位数增加211%）相比，幽门螺杆菌感染与较低的胃容受性相关（餐后恒压器气囊容积中位数增加75%）。一名幽门螺杆菌阳性受试者的腹部迷走神经功能测试异常，其胃容受性反应降低。两组的其他运动和感觉功能相似。在无症状志愿者中，幽门螺杆菌感染和胃炎导致胃容受性降低（舒张功能障碍），但胃的整体感觉或运动功能无变化。
