von Rückmann A, Fitzke F W, Gregor Z J
Moorfields Eye Hospital, London.
Br J Ophthalmol. 1998 Apr;82(4):346-51. doi: 10.1136/bjo.82.4.346.
To demonstrate the usefulness of a recently developed technique of imaging fundus autofluorescence and to compare it with the results of fluorescein angiography in the diagnosis and staging of macular holes.
The intensity and distribution of fundus autofluorescence was studied in 51 patients with idiopathic macular holes and pseudoholes using a confocal laser scanning ophthalmoscope (cLSO) and the images were compared with those obtained by fundus fluorescein angiography.
Autofluorescence imaging demonstrated bright fluorescence of macular holes with appearance similar to that obtained by fluorescein angiography. In contrast macular pseuodoholes showed no such autofluorescence. The attached operculum in stage 2 macular holes and the preretinal operculum in stage 3 macular holes showed focal decreased autofluorescence. The associated retinal elevation and the cuff of subretinal fluid were less fluorescent compared with the background autofluorescence of the normal fellow eyes. Following successful surgical treatment the autofluorescence of the macular holes was no longer visible.
Autofluorescence imaging with the cLSO makes the assessment of macular holes possible with an accuracy comparable with that of fluorescein angiography. Being non-invasive and rapid, autofluorescence imaging may become a useful alternative to fluorescein angiography in the assessment and the differential diagnosis of full thickness macular holes.
证明一种最近开发的眼底自发荧光成像技术的实用性，并将其与荧光素血管造影在黄斑裂孔诊断和分期中的结果进行比较。
使用共焦激光扫描检眼镜（cLSO）研究了51例特发性黄斑裂孔和假性裂孔患者的眼底自发荧光强度和分布，并将图像与眼底荧光素血管造影获得的图像进行比较。
自发荧光成像显示黄斑裂孔有明亮荧光，其外观与荧光素血管造影获得的相似。相比之下，黄斑假性裂孔没有这种自发荧光。2期黄斑裂孔中的附着盖膜和3期黄斑裂孔中的视网膜前盖膜显示局部自发荧光降低。与正常对侧眼的背景自发荧光相比，相关的视网膜隆起和视网膜下液袖带荧光较弱。成功手术治疗后，黄斑裂孔的自发荧光不再可见。
使用cLSO进行自发荧光成像使得评估黄斑裂孔成为可能，其准确性与荧光素血管造影相当。由于是非侵入性且快速的，自发荧光成像可能成为荧光素血管造影在全层黄斑裂孔评估和鉴别诊断中的有用替代方法。
