Lewindon P J, Harkness L, Lewindon N
Women's and Children's Hospital, Adelaide, South Australia.
Arch Dis Child. 1998 May;78(5):453-6. doi: 10.1136/adc.78.5.453.
To evaluate the effect of sucrose solution given by mouth on infant crying times and measures of distress in the immunisation clinic.
Randomised, double blind, placebo controlled trial of sucrose solution 75% wt/vol v sterile water as a control.
The immunisation clinic of the Women's and Children's Hospital, Adelaide.
A total of 107 healthy infants attending for 2, 4, or 6 month immunisations with polio by mouth (Sabin), intramuscular diphtheria, tetanus, and pertussis (DTP), and intramuscular Haemophilus influenzae type b were randomised to receive 2 ml 75% sucrose solution or sterile water by mouth before the two injections.
The duration of infant crying was recorded during and immediately after two intramuscular immunisations and infant distress was assessed by a visual analogue scale (Oucher scores) independently by a nurse and a parent.
The administration of 2 ml 75% sucrose solution by mouth reduced the infant crying time and Oucher distress scores after immunisation with DTP/H influenzae type b.
Infant immunisation by intramuscular injection is a distressing procedure for infants and parents. Sucrose solution at a high concentration reduces infant distress and is safe and clinically useful in this setting.
评估口服蔗糖溶液对免疫接种门诊中婴儿哭闹时间及痛苦程度指标的影响。
采用随机、双盲、安慰剂对照试验，以75%重量/体积的蔗糖溶液作为实验组，无菌水作为对照组。
阿德莱德妇女儿童医院的免疫接种门诊。
共有107名健康婴儿，前来接受2、4或6月龄的口服脊髓灰质炎（萨宾株）、肌内注射白喉、破伤风和百日咳（DTP）以及肌内注射b型流感嗜血杆菌疫苗接种。这些婴儿被随机分为两组，在两次注射前分别口服2毫升75%的蔗糖溶液或无菌水。
在两次肌内注射期间及注射后立即记录婴儿哭闹的持续时间，并由一名护士和一名家长分别使用视觉模拟评分法（面部表情疼痛评分量表）独立评估婴儿的痛苦程度。
口服2毫升75%的蔗糖溶液可缩短婴儿在接种DTP/b型流感嗜血杆菌疫苗后的哭闹时间，并降低面部表情疼痛评分量表的痛苦得分。
对婴儿进行肌内注射免疫接种对婴儿和家长来说是一个痛苦的过程。高浓度蔗糖溶液可减轻婴儿的痛苦，在此情况下安全且具有临床实用性。
