Shiraki K, Moriwaki M, Matsumoto M, Yanagihara N, Yasunari T, Miki T
Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan.
Int Ophthalmol. 1997;21(5):245-53. doi: 10.1023/a:1006038621426.
The severe types of central serous chorioretinopathy (CSC) have a chronic nature, suggesting that a pathological process persists subclinically. Indocyanine green (ICG) angiography recently revealed intrachoroidal dye leakage and its static nature in CSC. As the intrachoroidal dye leakage was suspected to be relevant to the disease process, the long-term persistence of intrachoroidal ICG leakage was examined in four patients of the severe types of CSC.
ICG angiography was performed periodically over more than three years in three patients and two years in one patient. One patient had CSC with bullous retinal detachment, and the other three had chronic CSC or diffuse retinal pigment epitheliopathy.
Intrachoroidal ICG leakage persisted in all the patients. However, a change in location of persistent intrachoroidal leakage or disappearance of intrachoroidal leakage regardless of no progression of retinal pigment epithelial alteration was noted in one eye of two patients.
Pathology causing intrachoroidal ICG leakage persisted subclinically for a long period. However, location and extent of the intrachoroidal leakage could change during a long-term follow-up period.
严重型中心性浆液性脉络膜视网膜病变（CSC）具有慢性病程，提示存在亚临床持续的病理过程。吲哚青绿（ICG）血管造影术最近揭示了CSC患者脉络膜内染料渗漏及其静止特性。由于怀疑脉络膜内染料渗漏与疾病进程相关，因此对4例严重型CSC患者脉络膜内ICG渗漏的长期持续性进行了研究。
3例患者在3年多的时间里定期进行ICG血管造影，1例患者在2年时间里定期进行。1例患者患有伴有大泡性视网膜脱离的CSC，另外3例患有慢性CSC或弥漫性视网膜色素上皮病变。
所有患者脉络膜内ICG渗漏均持续存在。然而，在2例患者的一只眼中，观察到持续性脉络膜内渗漏的位置改变或脉络膜内渗漏消失，尽管视网膜色素上皮改变没有进展。
导致脉络膜内ICG渗漏的病理过程在亚临床状态下长期持续存在。然而，在长期随访期间，脉络膜内渗漏的位置和范围可能会发生变化。
