Schmidt R, Hayn M, Reinhart B, Roob G, Schmidt H, Schumacher M, Watzinger N, Launer L J
Department of Neurology, Karl-Franzens University Graz, Austria.
J Am Geriatr Soc. 1998 Nov;46(11):1407-10. doi: 10.1111/j.1532-5415.1998.tb06008.x.
To study the association between cognitive status and plasma concentrations of various antioxidants in middle-aged and older individuals without neuropsychiatric disease.
Evaluation of cross-sectional data from a cohort study.
The Austrian Stroke Prevention Study.
A total of 1769 subjects aged 50 to 75 years, with no history or signs of neuropsychiatric disease, selected randomly from the community register.
The score on the Mattis Dementia Rating Scale (MDRS) was dichotomized according to age-and education-specific lowest quartile cut-off points. Reversed-phase high performance liquid chromatography measurements of the plasma concentrations of lutein/zeaxanthin, cryptoxanthin, canthaxanthin, lycopene, alpha-carotene, beta-carotene, retinol, gamma-tocopherol, alpha-tocopherol, and ascorbate were measured.
Individuals with MDRS results below the lowest quartile cut-off point had lower levels of beta-carotene and alpha-tocopherol than their counterparts with test performance above this limit (0.44+/-.33 micromol/L vs 0.51+/-.48 micromol/L, P < .001; and 29.50+/-7.98 micromol/L vs 30.93+/-11.10 micromol/L, P < .001, respectively). Only alphatocopherol remained significantly associated with cognitive functioning when logistic regression analysis was used to adjust for possible confounders including age, sex, month of blood sampling, years of education, smoking, lipid status, and major risk factors for stroke (P = .019).
These observations are compatible with the view that some dietary antioxidants may protect against cognitive impairment in older people.
研究无神经精神疾病的中老年人认知状态与多种抗氧化剂血浆浓度之间的关联。
对一项队列研究的横断面数据进行评估。
奥地利卒中预防研究。
从社区登记册中随机选取的1769名年龄在50至75岁之间、无神经精神疾病病史或体征的受试者。
根据年龄和教育程度特异性最低四分位数切点，将马蒂斯痴呆评定量表（MDRS）得分进行二分法划分。采用反相高效液相色谱法测量血浆中叶黄素/玉米黄质、隐黄质、角黄素、番茄红素、α-胡萝卜素、β-胡萝卜素、视黄醇、γ-生育酚、α-生育酚和抗坏血酸的浓度。
MDRS结果低于最低四分位数切点的个体，其β-胡萝卜素和α-生育酚水平低于测试表现高于该切点的个体（分别为0.44±0.33微摩尔/升对0.51±0.48微摩尔/升，P<0.001；以及29.50±7.98微摩尔/升对30.93±11.10微摩尔/升，P<0.001）。在使用逻辑回归分析对可能的混杂因素（包括年龄、性别、采血月份、教育年限、吸烟、血脂状况和卒中主要危险因素）进行校正后，仅α-生育酚与认知功能仍存在显著关联（P = 0.019）。
这些观察结果与某些膳食抗氧化剂可能预防老年人认知障碍的观点相符。
