PCR-restriction fragment length polymorphism can also detect point mutation A2142C in the 23S rRNA gene, associated with Helicobacter pylori resistance to clarithromycin.
作者信息
Ménard Armelle, Santos Adriana, Mégraud Francis, Oleastro Mónica
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1156-7. doi: 10.1128/AAC.46.4.1156-1157.2002.
Abstract
摘要
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PCR-restriction fragment length polymorphism can also detect point mutation A2142C in the 23S rRNA gene, associated with Helicobacter pylori resistance to clarithromycin.聚合酶链反应-限制性片段长度多态性分析也可检测23S rRNA基因中的点突变A2142C，该突变与幽门螺杆菌对克拉霉素的耐药性有关。
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Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study.通过用于检测23S rRNA基因突变的PCR线探针检测法准确预测幽门螺杆菌对大环内酯类药物的耐药性：多中心验证研究
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PCR-based diagnosis of Helicobacter pylori infection and real-time determination of clarithromycin resistance directly from human gastric biopsy samples.基于聚合酶链反应的幽门螺杆菌感染诊断及直接从人胃活检样本中实时测定克拉霉素耐药性
J Clin Microbiol. 2001 Apr;39(4):1217-20. doi: 10.1128/JCM.39.4.1217-1220.2001.
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Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.快速检测幽门螺杆菌23S rRNA基因中的突变，这些突变使该细菌对克拉霉素治疗产生耐药性。
J Clin Microbiol. 2001 Feb;39(2):691-5. doi: 10.1128/JCM.39.2.691-695.2001.
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Novel method for rapid determination of clarithromycin sensitivity in Helicobacter pylori.快速测定幽门螺杆菌对克拉霉素敏感性的新方法。
J Clin Microbiol. 1999 Nov;37(11):3746-8. doi: 10.1128/JCM.37.11.3746-3748.1999.
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Rapid detection, by PCR and reverse hybridization, of mutations in the Helicobacter pylori 23S rRNA gene, associated with macrolide resistance.通过聚合酶链反应（PCR）和反向杂交技术快速检测与大环内酯类耐药相关的幽门螺杆菌23S rRNA基因突变。
Antimicrob Agents Chemother. 1999 Jul;43(7):1779-82. doi: 10.1128/AAC.43.7.1779.
6
Direct detection of Helicobacter pylori resistance to macrolides by a polymerase chain reaction/DNA enzyme immunoassay in gastric biopsy specimens.通过聚合酶链反应/DNA酶免疫测定法直接检测胃活检标本中幽门螺杆菌对大环内酯类药物的耐药性。
Gut. 1999 Apr;44(4):463-7. doi: 10.1136/gut.44.4.463.
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Detection of point mutations associated with resistance of Helicobacter pylori to clarithromycin by hybridization in liquid phase.通过液相杂交检测幽门螺杆菌对克拉霉素耐药相关的点突变
J Clin Microbiol. 1998 Nov;36(11):3285-90. doi: 10.1128/JCM.36.11.3285-3290.1998.
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Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes.幽门螺杆菌对大环内酯类药物的耐药性：点突变的快速检测及大环内酯类药物与核糖体结合的测定
Antimicrob Agents Chemother. 1997 Dec;41(12):2724-8. doi: 10.1128/AAC.41.12.2724.
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Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations.幽门螺杆菌23S rRNA基因两个拷贝的克隆与序列分析以及克拉霉素耐药性与23S rRNA突变的关联
Antimicrob Agents Chemother. 1997 Dec;41(12):2621-8. doi: 10.1128/AAC.41.12.2621.
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Macrolide resistance in Helicobacter pylori: mechanism and stability in strains from clarithromycin-treated patients.幽门螺杆菌对大环内酯类药物的耐药性：来自克拉霉素治疗患者菌株的机制与稳定性
Antimicrob Agents Chemother. 1997 Nov;41(11):2550-3. doi: 10.1128/AAC.41.11.2550.
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