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本文引用的文献

1
Comparative analysis of Clostridium difficile clinical isolates belonging to different genetic lineages and time periods.不同遗传谱系和时间段的艰难梭菌临床分离株的比较分析。
J Med Microbiol. 2004 Nov;53(Pt 11):1129-1136. doi: 10.1099/jmm.0.45682-0.
2
Phenotypic and genotypic characterization of two penicillin-susceptible serotype 6B Streptococcus pneumoniae clones circulating in Italy.在意大利传播的两个对青霉素敏感的6B型肺炎链球菌克隆株的表型和基因型特征
J Clin Microbiol. 2003 Jul;41(7):2855-61. doi: 10.1128/JCM.41.7.2855-2861.2003.
3
Analysis of macrolide-lincosamide-streptogramin B (MLS(B)) resistance determinant in strains of Clostridium difficile.艰难梭菌菌株中大环内酯-林可酰胺-链阳菌素B（MLS(B)）耐药决定因素的分析
Microb Drug Resist. 2002 Spring;8(1):45-53. doi: 10.1089/10766290252913755.
4
Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile.艰难梭菌红霉素抗性元件Tn5398的基因组分析。
Microbiology (Reading). 2001 Oct;147(Pt 10):2717-2728. doi: 10.1099/00221287-147-10-2717.
5
Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules.艰难梭菌的Tn5397、粪肠球菌的Tn916和产气荚膜梭菌的CW459tet(M)元件的比较表明，它们具有相似的接合区域，但插入和切除模块不同。
Microbiology (Reading). 2001 May;147(Pt 5):1243-1251. doi: 10.1099/00221287-147-5-1243.
6
Demonstration that the group II intron from the Clostridial Conjugative transposon Tn5397 undergoes splicing In vivo.证明来自梭菌接合转座子Tn5397的II组内含子在体内发生剪接。
J Bacteriol. 2001 Feb;183(4):1296-9. doi: 10.1128/JB.183.4.1296-1299.2001.
7
DNA sequence of the insertional hot spot of Tn916 in the Clostridium difficile genome and discovery of a Tn916-like element in an environmental isolate integrated in the same hot spot.艰难梭菌基因组中Tn916插入热点的DNA序列以及在整合于同一热点的环境分离株中发现类Tn916元件
FEMS Microbiol Lett. 2000 Nov 1;192(1):15-20. doi: 10.1111/j.1574-6968.2000.tb09352.x.
8
Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX.艰难梭菌新型接合转座子Tn5397末端及靶位点的特征：切除和环化由大型解离酶TndX介导。
J Bacteriol. 2000 Jul;182(13):3775-83. doi: 10.1128/JB.182.13.3775-3783.2000.
9
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.艰难梭菌630的大环内酯-林可酰胺-链阳霉素B耐药决定簇包含两个erm(B)基因。
Antimicrob Agents Chemother. 2000 Feb;44(2):411-3. doi: 10.1128/AAC.44.2.411-413.2000.
10
Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants.Tn916家族接合转座子与抗菌耐药决定因子的传播
Antimicrob Agents Chemother. 1998 Aug;42(8):1871-7. doi: 10.1128/AAC.42.8.1871.

艰难梭菌临床分离株中的ErmB决定簇和类Tn916元件

ErmB determinants and Tn916-Like elements in clinical isolates of Clostridium difficile.

作者信息

Spigaglia Patrizia, Carucci Valentina, Barbanti Fabrizio, Mastrantonio Paola

机构信息

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2550-3. doi: 10.1128/AAC.49.6.2550-2553.2005.

DOI:10.1128/AAC.49.6.2550-2553.2005
PMID:15917571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140533/
Abstract

Erythromycin and tetracycline resistance was analyzed in 37 Clostridium difficile clinical isolates. Strains of different clonal origins showed different erythromycin and tetracycline resistance determinants and different genetic arrangements of the elements. In strains of recent isolation, the presence of Tn916-like elements, never found before in C. difficile clinical isolates, has been demonstrated.

摘要

对37株艰难梭菌临床分离株进行了红霉素和四环素耐药性分析。不同克隆起源的菌株表现出不同的红霉素和四环素耐药决定因素以及这些元件的不同基因排列。在近期分离的菌株中，已证实存在之前在艰难梭菌临床分离株中从未发现过的Tn916样元件。