Riddell R H, Tanaka M, Mazzoleni G
Department of Pathology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Gut. 1992 May;33(5):683-6. doi: 10.1136/gut.33.5.683.
The use of oral non-steroidal anti-inflammatory drugs (NSAIDs) in 31 patients with collagenous colitis and in 31 matched control patients with irritable bowel syndrome or colonic diverticular disease who had also undergone colonoscopy and biopsy was investigated. The long term use (greater than 6 months) of NSAIDs was significantly commoner in the study group (19/31) than in the control group (4/31) (p less than 0.02), even assuming the most adverse drug history in six patients in whom this could not be established. In all patients with collagenous colitis taking NSAIDs, diarrhoea followed the use of these drugs, and by a mean (SD) of 5.5 (4.4) years (range 0.5 to 15 years). In three patients with collagenous colitis, diarrhoea improved after withdrawing NSAIDs; rechallenge in one was followed by a recurrence of diarrhoea, which improved after withdrawing the drug again. It is suggested that NSAIDs may play an aetiological role in the diarrhoea and thickened collagen band in some patients with collagenous colitis.
对31例胶原性结肠炎患者以及31例同样接受过结肠镜检查和活检的、与之匹配的肠易激综合征或结肠憩室病对照患者使用口服非甾体抗炎药（NSAIDs）的情况进行了调查。研究组中NSAIDs的长期使用（超过6个月）（19/31）明显比对照组（4/31）更为常见（p<0.02），即使在6例无法确定用药史的患者中假设最不利的用药史也是如此。在所有服用NSAIDs的胶原性结肠炎患者中，腹泻均在使用这些药物后出现，平均（标准差）为5.5（4.4）年（范围0.5至15年）。在3例胶原性结肠炎患者中，停用NSAIDs后腹泻改善；其中1例再次用药后腹泻复发，再次停药后改善。提示NSAIDs可能在某些胶原性结肠炎患者的腹泻和胶原带增厚中起病因学作用。
