热量限制的影响因物种而异。
Effects of caloric restriction are species-specific.
作者信息
Mockett Robin J, Cooper T Michael, Orr William C, Sohal Rajindar S
机构信息
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.
出版信息
Biogerontology. 2006 Jun;7(3):157-60. doi: 10.1007/s10522-006-9004-3.
This article addresses two questions: (1) 'can caloric restriction (CR) extend the life spans of all species of experimental animals', and (2) 'is CR likely to slow the human aging process and/or extend the human life span?' The answer to the first question is clearly 'no', because CR decreases the life span of the housefly, Musca domestica, and fails to extend the life span of at least one mouse strain. The answer to the second question is unknown, because human CR has not yet been shown either to increase or curtail the human life span. However, recent efforts to develop insect models of CR have been unsuccessful and/or relatively uninformative, so any insights regarding the relationship between CR and human aging are more likely to arise from studies of established, mammalian models of CR.
本文探讨了两个问题
（1）“热量限制（CR）能否延长所有实验动物物种的寿命”，以及（2）“热量限制是否可能减缓人类衰老过程和/或延长人类寿命？” 第一个问题的答案显然是 “否”，因为热量限制会缩短家蝇（Musca domestica）的寿命，并且未能延长至少一种小鼠品系的寿命。第二个问题的答案尚不清楚，因为尚未证明人类进行热量限制会增加或缩短人类寿命。然而，最近开发热量限制昆虫模型的努力并不成功和/或提供的信息相对较少，因此，关于热量限制与人类衰老之间关系的任何见解更有可能来自对已确立的热量限制哺乳动物模型的研究。
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