移植患者巨细胞病毒检测：前瞻性调查中不同方法的比较
Cytomegalovirus detection in transplant patients: comparison of different methods in a prospective survey.
作者信息
Wunderli W, Auracher J D, Zbinden R
机构信息
Institute of Immunology and Virology, University of Zürich, Switzerland.
出版信息
J Clin Microbiol. 1991 Nov;29(11):2648-50. doi: 10.1128/jcm.29.11.2648-2650.1991.
Abstract
In a prospective survey, all transplant patients at the hospital of the University of Zurich were screened for cytomegalovirus (CMV) infection. CMV infections were detected in a total of 40 of 104 transplant recipients; 31 could be diagnosed by CMV immunoglobulin M serology, 27 could be diagnosed by viremia, 11 could be diagnosed by antigenemia, and 13 could be diagnosed by the start of virus secretion. Combined application of serology and the detection of viremia showed the highest sensitivity (39 of 40 cases). Of the patients with severe clinical symptoms, six of seven had primary CMV infections caused by a positive transplant. Therefore, it is strongly indicated that patients with known risk factors should be regularly surveyed by a combination of methods.
摘要
在一项前瞻性调查中，苏黎世大学医院的所有移植患者均接受了巨细胞病毒（CMV）感染筛查。在104名移植受者中，共有40人检测出CMV感染；31例可通过CMV免疫球蛋白M血清学诊断，27例可通过病毒血症诊断，11例可通过抗原血症诊断，13例可通过病毒分泌开始诊断。血清学和病毒血症检测的联合应用显示出最高的敏感性（40例中的39例）。在有严重临床症状的患者中，7例中有6例因移植阳性而发生原发性CMV感染。因此，强烈建议对有已知危险因素的患者定期采用多种方法进行检查。
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