Hendrix M G, Daemen M, Bruggeman C A
Department of Medical Microbiology, University of Limburg, Maastricht, The Netherlands.
Am J Pathol. 1991 Mar;138(3):563-7.
The presence of human cytomegalovirus (HCMV) nucleic acids was demonstrated in almost all major arteries of HCMV-seropositive patients by polymerase chain reaction. The amount of HCMV nucleic acids present in the arterial wall was calculated to be less than 2 viral genomic equivalents per 2500 human genomic equivalents. No relation was observed between the presence of HCMV nucleic acids in the arterial wall and the existence of atherosclerotic changes. No differences were observed in the number of viral genomic equivalents present at sites with or without atherosclerosis. Apart from a role for HCMV in the pathogenesis of atherosclerosis, the presence of latent HCMV in the arterial tree provides a powerful system to describe the physical state of this latently present virus.
通过聚合酶链反应在巨细胞病毒血清反应阳性患者的几乎所有主要动脉中都检测到了人巨细胞病毒（HCMV）核酸。经计算，动脉壁中存在的HCMV核酸量低于每2500个人基因组当量2个病毒基因组当量。未观察到动脉壁中HCMV核酸的存在与动脉粥样硬化病变的存在之间存在关联。在有或没有动脉粥样硬化的部位，病毒基因组当量的数量没有差异。除了HCMV在动脉粥样硬化发病机制中的作用外，动脉树中潜伏性HCMV的存在为描述这种潜伏病毒的物理状态提供了一个有力的系统。
