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中性粒细胞可能是人类H5N1禽流感病毒复制和传播的载体。

Neutrophils may be a vehicle for viral replication and dissemination in human H5N1 avian influenza.

作者信息

Zhao Yingying, Lu Min, Lau Lok Ting, Lu Jie, Gao Zifen, Liu Jinhua, Yu Albert Cheung Hoi, Cao Qi, Ye Juxiang, McNutt Michael A, Gu Jiang

机构信息

Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China.

出版信息

Clin Infect Dis. 2008 Dec 15;47(12):1575-8. doi: 10.1086/593196.

DOI:10.1086/593196
PMID:18990065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7107848/
Abstract

The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

摘要

H5N1病毒在禽流感患者体内的全身传播机制尚不清楚。在此，通过免疫组织化学在一名孕妇胎盘血中性粒细胞的细胞核和细胞质中鉴定出了H5N1核蛋白和血凝素。通过原位杂交和增强型实时聚合酶链反应在中性粒细胞中检测到病毒RNA。因此，中性粒细胞可能是禽流感病毒复制和传播的载体。

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