Watson Iain D G, Ritter Stefanie, Toste F Dean
Department of Chemistry, University of California, Berkeley, California 94720, USA.
J Am Chem Soc. 2009 Feb 18;131(6):2056-7. doi: 10.1021/ja8085005.
An efficient method for the asymmetric gold(I)-catalyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold(I)-stabilized vinyl carbenoid intermediates.
已开发出一种用于不对称金（I）催化制备中等大小环的有效方法。该方法能以优异的产率得到7至9元环。使用手性金（I）配合物时，7元和8元环产物可实现高对映选择性。这些结果为反应机理提供了见解，表明了金（I）稳定的乙烯基类卡宾中间体的动态性质。
