Takeshita E M, Castro L P, Sassaki K T, Delbem A C B
Araçatuba Dental School, UNESP-São Paulo State University, Araçatuba, Brazil.
Caries Res. 2009;43(1):50-6. doi: 10.1159/000196507. Epub 2009 Jan 28.
One way to reduce dental fluorosis is by reducing the fluoride (F) concentration in dentifrice, but low-F dentifrice should be as effective as a standard dentifrice. This study evaluated in vitro whether the supplementation with sodium trimetaphosphate (TMP) of a dentifrice with low F content (500 microg/g) would provide a similar effect to that of a standard dentifrice. Bovine enamel blocks were submitted to a pH cycling regime incorporating daily exposures to a slurry of dentifrice: a low-F dentifrice with or without 0.1-3.0% TMP; an F-free, phosphate-free dentifrice (negative control), or a dentifrice with 1,100 microg/g F (positive control). The addition of TMP to dentifrice with or without F was associated with higher surface hardness and decreased loss of integrated subsurface hardness after pH cycling. The combination of 1% TMP and 500 microg F/g had a greater effect than the positive control dentifrice. It is concluded that the addition of TMP to the 500-microg F/g dentifrice allowed a similar or larger effect as compared with a standard dentifrice in this in vitro model.
减少氟斑牙的一种方法是降低牙膏中的氟化物（F）浓度，但低氟牙膏应与标准牙膏具有相同的效果。本研究在体外评估了向低氟含量（500微克/克）的牙膏中添加三聚偏磷酸钠（TMP）是否会产生与标准牙膏类似的效果。将牛牙釉质块置于pH循环环境中，每天接触牙膏糊剂：含或不含0.1 - 3.0% TMP的低氟牙膏；无氟、无磷酸盐的牙膏（阴性对照），或含1100微克/克F的牙膏（阳性对照）。向含氟或不含氟的牙膏中添加TMP，在pH循环后，与更高的表面硬度和更低的整体次表面硬度损失相关。1% TMP与500微克F/克的组合比阳性对照牙膏具有更大的效果。得出的结论是，在这个体外模型中，向500微克F/克的牙膏中添加TMP与标准牙膏相比产生了相似或更大的效果。
