Valero A, Baró E, Sastre J, Navarro-Pulido A M, Izquierdo I, Martí-Guadaño E, Ferrer M, Dávila I, del Cuvillo A, Colas C, Antepara I, Alonso J, Mullol J
Allergy Unit, Pneumology and Allergy Department, Hospital Clinic, Barcelona, Spain.
J Investig Allergol Clin Immunol. 2009;19(5):396-403.
ESPRINT-15 is a specific, short-form instrument to measure health-related quality of life in adults suffering from allergic rhinitis. The aim of this study was to obtain reference values in order to improve its interpretability.
ESPRINT-15 was administered to a representative sample of Spanish adults with allergic rhinitis. Means and percentiles were obtained, taking into account the kind of rhinitis (persistent/intermittent) and symptom severity (very mild/mild/moderate/severe).
A total of 2756 patients participated in the study. Mean (SD) scores were significantly lower (better) for men than for women (2.2 [1.4] vs 2.4 [1.4], P<.001, effect size [ES] is congruent to 0.15). Patients with intermittent rhinitis showed better scores than patients with persistent rhinitis (2.1 [1.4] vs. 2.5 [1.4], P<.001, ES is congruent to 0.21). Mean (SD) scores were higher (worse) when severity of symptoms increased, ranging from 0.9 (0.9) (very mild) to 3.7 (1.0) (severe) (ES is congruent to 1.0 between each consecutive group of symptom severity).
The magnitude of the differences found among groups of patients reinforces the usefulness of providing reference values stratified by gender, type of allergic rhinitis, and symptom severity. The percentiles obtained can be used in clinical practice to evaluate individual scores, and assign the patient to the corresponding reference group.
ESPRINT - 15是一种用于测量过敏性鼻炎成年患者健康相关生活质量的特定简表工具。本研究的目的是获取参考值以提高其可解释性。
对西班牙成年过敏性鼻炎患者的代表性样本进行ESPRINT - 15测评。考虑到鼻炎类型(持续性/间歇性)和症状严重程度(非常轻微/轻微/中度/重度),得出均值和百分位数。
共有2756名患者参与研究。男性的平均(标准差)得分显著低于女性(2.2[1.4]对2.4[1.4],P <.001,效应量[ES]约为0.15)。间歇性鼻炎患者的得分优于持续性鼻炎患者(2.1[1.4]对2.5[1.4],P <.001,ES约为0.21)。症状严重程度增加时,平均(标准差)得分更高(更差),范围从0.9(0.9)(非常轻微)到3.7(1.0)(严重)(每连续一组症状严重程度之间的ES约为1.0)。
在患者组中发现的差异程度强化了提供按性别、过敏性鼻炎类型和症状严重程度分层的参考值的有用性。获得的百分位数可用于临床实践中评估个体得分,并将患者归入相应的参考组。