Department of Physical Medicine and Rehabilitation, Ataturk Training and Research Hospital, Ankara, Turkey.
Rheumatol Int. 2011 May;31(5):605-10. doi: 10.1007/s00296-009-1328-2. Epub 2010 Jan 5.
The aim of this study was to evaluate quality of life (QOL) in patients with ankylosing spondylitis (AS) and to determine the relationships between QOL and clinical variables including spinal mobility, disease activity and functional status. Forty-eight adult patients who fulfilled the modified New York criteria for AS were included in the study. After detailed physical examination, disease-specific instruments: the Bath ankylosing spondylitis disease activity index (BASDAI) and the Bath ankylosing spondylitis functional index (BASFI) were applied. QOL was assessed using short form-36 (SF-36). The mean age of the patients was 37.0 ± 9.7 years and the mean duration of symptoms was 11.7 ± 8.4 years. Most affected domains of SF-36 were bodily pain, vitality, and physical role, respectively. No significant correlations were found between SF-36 subgroup scores and chest expansion, wall-tragus distance, chin-sternum distance, and floor-finger tip distance. Only modified Schober correlated with two SF-36 domains: physical role and bodily pain. BASDAI and BASFI scores had significant negative correlations with all SF-36 domains except for general health. Identification of QOL in patients with AS is very important in evaluation of illness-related sufferings and development of new management strategies.
本研究旨在评估强直性脊柱炎（AS）患者的生活质量（QOL），并确定 QOL 与包括脊柱活动度、疾病活动度和功能状态在内的临床变量之间的关系。本研究纳入了 48 名符合改良纽约标准的成年 AS 患者。详细的体格检查后，应用特定疾病的工具：强直性脊柱炎疾病活动指数（BASDAI）和强直性脊柱炎功能指数（BASFI）。使用简明 36 项健康调查量表（SF-36）评估 QOL。患者的平均年龄为 37.0±9.7 岁，症状平均持续时间为 11.7±8.4 年。SF-36 中受影响最严重的领域分别为身体疼痛、活力和生理职能。SF-36 亚组评分与胸廓扩张度、耳垂-髂嵴距离、颈胸距离和指尖-地面距离之间无显著相关性。仅改良 Schober 与两个 SF-36 领域相关：生理职能和身体疼痛。BASDAI 和 BASFI 评分与除总体健康外的所有 SF-36 领域均呈显著负相关。识别 AS 患者的 QOL 在评估与疾病相关的痛苦和制定新的管理策略方面非常重要。
