Adeyemi David Olawale, Komolafe Omobola Aderibigbe, Adewole Olarinde Stephen, Obuotor Efere Martins, Adenowo Thomas Kehinde
Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile Ife, Nigeria.
Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):62-9.
This study was designed to determine the effects of methanolic extracts of Annona muricata (Linn) on the blood glucose level of streptozotocin-induced diabetic Wistar rats. Thirty adult Wistar rats were randomly assigned into three groups (A, B and C) of ten rats each. Group A was the control, Group B was untreated hyperglycemic group and group C was A. muricata-treated group. Hyperglycemia was induced in groups B and C by a single intraperitoneal injection of 80 mg/kg streptozotocin dissolved in 0.1 M citrate buffer. The control group was intraperitoneally injected with equivalent volume of citrate buffer and all the animals were monitored for four weeks. Daily intra peritoneal injection of 100 mg/kg A. muricata was administered to group C rats for two weeks and the animals were monitored for another two weeks. The data obtained were analyzed with descriptive and inferential statistics. The result showed a mean body weight of 206 +/- 7.74 g, 173.29+/-5.13 g and 197 +/- 5.62 g respectively for the control, untreated diabetic and A. muricata-treated diabetic group, and a mean blood glucose concentration of 3.78 +/- 0.190 mmol/L, 21.64 +/- 2.229 mmol/L and 4.22 +/- 0.151 mmol/L for the control, untreated diabetic and treated diabetic groups respectively. A significant difference exists between the blood glucose concentrations of treated and untreated hyperglycemic groups of rats. The result of this study demonstrated that A. muricata possesses anti-hyperglycemic activities.
本研究旨在确定番荔枝（Annona muricata Linn）甲醇提取物对链脲佐菌素诱导的糖尿病Wistar大鼠血糖水平的影响。30只成年Wistar大鼠被随机分为三组（A、B和C），每组10只。A组为对照组，B组为未治疗的高血糖组，C组为番荔枝治疗组。通过腹腔注射一次溶解于0.1 M柠檬酸盐缓冲液中的80 mg/kg链脲佐菌素，在B组和C组诱导高血糖。对照组腹腔注射等量的柠檬酸盐缓冲液，对所有动物监测四周。每天给C组大鼠腹腔注射100 mg/kg番荔枝，持续两周，并对动物再监测两周。对获得的数据进行描述性和推断性统计分析。结果显示，对照组、未治疗的糖尿病组和番荔枝治疗的糖尿病组的平均体重分别为206±7.74 g、173.29±5.13 g和197±5.62 g，对照组、未治疗的糖尿病组和治疗后的糖尿病组的平均血糖浓度分别为3.78±0.190 mmol/L、21.64±2.229 mmol/L和4.22±0.151 mmol/L。治疗组和未治疗的高血糖大鼠组的血糖浓度存在显著差异。本研究结果表明，番荔枝具有降血糖活性。
