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Genesis of a KPC-producing Klebsiella pneumoniae after in vivo transfer from an imported Greek strain.产 KPC 肺炎克雷伯菌的体内转移起源于一株从希腊进口的菌株。
Euro Surveill. 2010 Jan 7;15(1):19457. doi: 10.2807/ese.15.01.19457-en.
2
Detection of KPC in Acinetobacter spp. in Puerto Rico.波多黎各不动杆菌属中产 KPC 的检测。
Antimicrob Agents Chemother. 2010 Mar;54(3):1354-7. doi: 10.1128/AAC.00899-09. Epub 2009 Dec 28.
3
Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient.在单个患者中肠杆菌科碳青霉烯酶基因的种间传播。
Clin Infect Dis. 2009 Dec 1;49(11):1736-8. doi: 10.1086/648077.
4
Use of boronic acid disk tests to detect extended- spectrum beta-lactamases in clinical isolates of KPC carbapenemase-possessing enterobacteriaceae.使用硼酸盘试验检测产 KPC 碳青霉烯酶肠杆菌科临床分离株中的超广谱β-内酰胺酶。
J Clin Microbiol. 2009 Nov;47(11):3420-6. doi: 10.1128/JCM.01314-09. Epub 2009 Sep 2.
5
Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece.产KPC-2碳青霉烯酶肺炎克雷伯菌菌株在希腊的克隆传播。
J Antimicrob Chemother. 2009 Aug;64(2):348-52. doi: 10.1093/jac/dkp207. Epub 2009 Jun 13.
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Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
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First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests.希腊一家医院首次出现携带KPC-2的肺炎克雷伯菌及硼酸纸片试验检测建议。
J Antimicrob Chemother. 2008 Dec;62(6):1257-60. doi: 10.1093/jac/dkn364. Epub 2008 Sep 4.
8
Detection of KPC-2 in a clinical isolate of Proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC beta-lactamase in P. mirabilis.奇异变形杆菌临床分离株中KPC-2的检测及首例关于奇异变形杆菌中KPCβ-内酰胺酶引起碳青霉烯类耐药的报道。
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Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France.对在法国从同一患者分离出的一株大肠杆菌和一株阴沟肠杆菌中鉴定出的超广谱A类β-内酰胺酶KPC-2的传播潜力的遗传学和结构见解。
Antimicrob Agents Chemother. 2008 Oct;52(10):3725-36. doi: 10.1128/AAC.00163-08. Epub 2008 Jul 14.
10
Detection of the Klebsiella pneumoniae carbapenemase type 2 Carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid.在携带共同质粒的弗氏柠檬酸杆菌和产酸克雷伯菌临床分离株中检测2型肺炎克雷伯菌碳青霉烯酶（一种碳青霉烯水解酶）
J Clin Microbiol. 2008 Jun;46(6):2066-9. doi: 10.1128/JCM.02038-07. Epub 2008 Apr 2.

在粘质沙雷氏菌克隆株中获得一种质粒介导的 bla(KPC-2) 基因。

In vivo acquisition of a plasmid-mediated bla(KPC-2) gene among clonal isolates of Serratia marcescens.

机构信息

Department of Microbiology, Medical School, University of Athens, Athens, Greece.

出版信息

J Clin Microbiol. 2010 Jul;48(7):2546-9. doi: 10.1128/JCM.00264-10. Epub 2010 May 12.

DOI:10.1128/JCM.00264-10
PMID:20463153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2897482/
Abstract

Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. marcescens isolates. Molecular typing and plasmid analysis suggested that all three patients had clonally indistinguishable isolates of S. marcescens that acquired a plasmid-mediated bla(KPC-2) gene during the hospitalization.

摘要

三名入住希腊医院的患者感染了对碳青霉烯类药物敏感性降低的粘质沙雷氏菌分离株，这些分离株携带产碳青霉烯酶肺炎克雷伯菌（KPC）。在这两例患者中，最初感染的是对碳青霉烯类药物敏感的粘质沙雷氏菌分离株。分子分型和质粒分析表明，所有这三例患者的粘质沙雷氏菌分离株均具有克隆不可区分的特征，这些分离株在住院期间获得了一种质粒介导的bla(KPC-2)基因。