Perez Maritza, Luke Janiene, Rossi Anthony
Skin of Color Center at St. Luke's/Roosevelt Hospital Center, New York, NY, USA.
J Drugs Dermatol. 2011 May;10(5):517-23.
Melasma is an acquired skin condition characterized by irregular brown or hyperpigmented patches typically located on the forehead, cheeks, nose, chin and upper lip. The pathogenesis of melasma is not completely understood, but is thought to be influenced by genetics, UV exposure, thyroid dysfunction and hormonal influences from either pregnancy or hormonal therapeutic medications. Peoples of Latin descent comprise a vast array of skin colors and skin phototypes. Similarly, disorders of pigmentation, particularly melasma, occur more frequently in people of Latin descent when compared to the general population. Melasma can be particularly distressing to patients and has been shown to impact a patient's quality of life in several studies. These factors can raise significant quality of life issues and therefore treatment is not only significant for improving patient clinical outcomes, but is crucial in improving important psychological and emotional aspects of patients' overall well being. This article provides a stepwise approach to the treatment of melasma based on current literature recommendations.
黄褐斑是一种后天性皮肤疾病，其特征为不规则的褐色或色素沉着斑，通常位于前额、脸颊、鼻子、下巴和上唇。黄褐斑的发病机制尚未完全明确，但一般认为受遗传、紫外线照射、甲状腺功能障碍以及妊娠或激素治疗药物的激素影响。拉丁裔人群包含多种肤色和皮肤光类型。同样，与普通人群相比，色素沉着紊乱，尤其是黄褐斑，在拉丁裔人群中更为常见。黄褐斑会给患者带来极大困扰，多项研究表明它会影响患者的生活质量。这些因素会引发严重的生活质量问题，因此治疗不仅对改善患者的临床结局具有重要意义，对于提升患者整体健康的重要心理和情感方面也至关重要。本文根据当前文献建议，提供了一种黄褐斑治疗的分步方法。
