铑(III)催化 5-芳基-1H-吡唑与炔烃和丙烯酸酯的氧化偶联。
Rhodium(III)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China.
出版信息
J Org Chem. 2011 Oct 21;76(20):8530-6. doi: 10.1021/jo201530r. Epub 2011 Sep 26.
PMID:21913640
Abstract
RhCp*Cl(2)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates has been achieved using Cu(OAc)(2) as an oxidant. Coupling with alkynes afforded six-membered azacycles as a result of C-C and C-N coupling. Coupling with acrylates followed a process of diolefination and a subsequent aza-Michael cyclization.
摘要
RhCp*Cl(2) 催化 5-芳基-1H-吡唑与炔烃和丙烯酸酯的氧化偶联反应，使用 Cu(OAc)(2) 作为氧化剂。与炔烃的偶联反应导致 C-C 和 C-N 偶联，生成六元氮杂环。与丙烯酸酯的偶联反应遵循双烯烃化和随后的氮杂-Michael 环化过程。
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