Trianto Agus, Hermawan Idam, de Voogd Nicole Joy, Tanaka Junichi
Department of Marine Sciences, Faculty of Fisheries and Marine Sciences, University of Diponegoro, Semarang, Central Java, Indonesia.
Chem Pharm Bull (Tokyo). 2011;59(10):1311-3. doi: 10.1248/cpb.59.1311.
Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC50 4.8 µg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 3.2 µg/ml.
对一种海绵Haliclona sp.进行的化学研究发现了一种具有新碳骨架的单萜1。通过分析光谱数据，阐明其结构包含一个取代对苯二酚、一个四氢氧杂环庚三烯和一个环己烯，并且这些组分通过C1和C2单元连接在一起。化合物1对NBT-T2细胞显示出中等细胞毒性，IC50为4.8 µg/ml，并且对1,1-二苯基-2-苦基肼（DPPH）具有抗氧化活性，IC50为3.2 µg/ml。
